I know this thread is a few month old but I wanted to add my experience to anyone considering microdosing.
Recently, I acquired 3 - 12" cuttings of some T. Bridgesii. I decided to do a potency test as my wife and I are planning a camping trip to watch the Perseid meteor showers Aug 12-13th and I don't want to blow her out of the water with her first cactus journey.
What I did was cut one of the 12" pieces into thirds - 4" for consumption and the other two 4" pieces were planted. The piece to be eaten was sliced into 1/2" cucumber like slices. I cut out the core and peeled the hard outer skin away and started to chomp away. Everybody says it tastes horrible and I won't dispute that but I expected much worse reading other reports. Honestly, I've had IPA beers that tasted nearly as bitter so in my mind it wasn't so horrific. I tried salting some of the pieces and with others added a dash of cholula hot sauce. That also helped slightly tame the bitter taste.
I ate them on an empty stomach around 9:00 am - fully chewing each bite in all its bitter glory. Around 10:15 I started to notice some subtle effects - for instance, words on my computer monitor were having a bit of 3D effect to them and I was feeling a pleasant body glow. Nothing overly weird or unnerving, but definitely different and fun. I liken the feeling to a light dose of MDMA.
At this point I thought it was time to do some yard work and get some fresh air. What followed for the next 8 hours was a real burst of energy and focus and boy did I accomplish a ton of shit! For some reason things that I ordinarily overlook or accept "as is" now drove me bonkers. A perfect example is my bathroom closets and medicine cabinet. In the past I would just search about looking for something and likely creating disarray in the process. Also, sometime last year I had spilled some cough syrup on the top shelf and didn't properly clean it up resulting in a never ending bit of stickiness. Yes, kind of gross but I was just overlooking it in my laziness.
Fast forward 8 hours and my yard looks awesome, my bathroom closets are immaculately organized, I vacuumed and mopped the entire house, washed and folded all the laundry, cleaned my car, paid some bills that I had neglected, and lastly cooked dinner for me and my wife. She arrived home home and was quite pleased to say the least:). And I won't complain how the rest of the night went either!!
Overall it was a fantastic day. I was really flowing, focused and having fun. The only drawback I felt was a bit more sweating than normal and falling asleep was a bit of a chore.