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Magic mushrooms may 'reset' the brains of depressed patients


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#1 Tenderfoot

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Posted 14 October 2017 - 08:15 AM

Thought I would share this!

 

https://medicalxpres...-depressed.html

 

Patients taking psilocybin to treat depression show reduced symptoms weeks after treatment following a 'reset' of their brain activity.

The findings come from a study in which researchers from Imperial College London used psilocybin - the psychoactive compound that occurs naturally in magic mushrooms - to treat a small number of patients with depression in whom conventional treatment had failed.

In a paper, published today in the journal Scientific Reports, the researchers describe patient-reported benefits lasting up to five weeks after treatment, and believe the psychedelic compound may effectively reset the activity of key brain circuits known to play a role in depression.

Comparison of images of patients' brains before and one day after they received the drug treatment revealed changes in brain activity that were associated with marked and lasting reductions in depressive symptoms.

The authors note that while the initial results of the experimental therapy are exciting, they are limited by the small sample size as well as the absence of a control group - such as a placebo group - to directly contrast with the patients.

Dr Robin Carhart-Harris, Head of Psychedelic Research at Imperial, who led the study, said: "We have shown for the first time clear changes in brain activity in depressed people treated with psilocybin after failing to respond to conventional treatments.

"Several of our patients described feeling 'reset' after the treatment and often used computer analogies. For example, one said he felt like his brain had been 'defragged' like a computer hard drive, and another said he felt 'rebooted'. Psilocybin may be giving these individuals the temporary 'kick start' they need to break out of their depressive states and these imaging results do tentatively support a 'reset' analogy. Similar brain effects to these have been seen with electroconvulsive therapy."

Over the last decade or so, a number of clinical trials have been conducted into the safety and effectiveness of psychedelics in patients with conditions such as depression and addictions, yielding promising results.

In the recent Imperial trial, the first with psilocybin in depression, 20 patients with treatment-resistant form of the disorder were given two doses of psilocybin (10 mg and 25 mg), with the second dose a week after the first.

Nineteen of these underwent initial brain imaging and then a second scan one day after the high dose treatment. Carhart-Harris and team used two main brain imaging methods to measure changes in blood flow and the crosstalk between brain regions, with patients reporting their depressive symptoms through completing clinical questionnaires.

Immediately following treatment with psilocybin, patients reported a decrease in depressive symptoms - corresponding with anecdotal reports of an 'after-glow' effect characterised by improvements in mood and stress relief.

Functional MRI imaging revealed reduced blood flow in areas of the brain, including the amygdala, a small, almond-shaped region of the brain known to be involved in processing emotional responses, stress and fear. They also found increased stability in another brain network, previously linked to psilocybin's immediate effects as well as to depression itself.

These findings provide a new window into what happens in the brains of people after they have 'come down' from a psychedelic, where an initial disintegration of brain networks during the drug 'trip', is followed by a re-integration afterwards.

Dr Carhart-Harris explained: "Through collecting these imaging data we have been able to provide a window into the after effects of psilocybin treatment in the brains of patients with chronic depression. Based on what we know from various brain imaging studies with psychedelics, as well as taking heed of what people say about their experiences, it may be that psychedelics do indeed 'reset' the brain networks associated with depression, effectively enabling them to be lifted from the depressed state.

The authors warn that while the initial findings are encouraging, the research is at an early stage and that patients with depression should not attempt to self-medicate, as the team provided a special therapeutic context for the drug experience and things may go awry if the extensive psychological component of the treatment is neglected. They add that future studies will include more robust designs and currently plan to test psilocybin against a leading antidepressant in a trial set to start early next year.

Professor David Nutt, Edmond J. Safra Professor of Neuropsychopharmacology and director of the Neuropsychopharmacology Unit in the Division of Brain Sciences, and senior author of the paper, added: "Larger studies are needed to see if this positive effect can be reproduced in more patients. But these initial findings are exciting and provide another treatment avenue to explore."

'Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms' by Carhart-Harris, R, et al. is published in the journal Scientific Reports.

Explore further: Magic mushroom compound psilocybin could provide new avenue for antidepressant research

More information: Robin L Carhart-Harris et al, Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms, Scientific Reports (2017). DOI: 10.1038/s41598-017-13282-7

Journal reference: Scientific Reports

 

 


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#2 whirledpeas

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Posted 14 October 2017 - 08:30 AM

O i love this thank you :)


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#3 bennylava

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Posted 16 October 2017 - 01:16 PM

Well it definitely reset mine, and cured my depressive tendencies. Soul crushingly, but it still did it.


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#4 Heirloom

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Posted 16 October 2017 - 02:49 PM

Thanks Tenderfoot. Mushrooms made a huge difference in my life and relieved terrible depression, I still take some on occasion to help, better than anti-depressants by a lightyear. I recommend them to people I meet and am willing to supply for free, now I only grow exotics like Psilocybe Mexicana and Psilocybe Cyanescens so a person needs only a very small amount.
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#5 bennylava

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Posted 17 November 2017 - 07:04 PM

Thanks Tenderfoot. Mushrooms made a huge difference in my life and relieved terrible depression, I still take some on occasion to help, better than anti-depressants by a lightyear. I recommend them to people I meet and am willing to supply for free, now I only grow exotics like Psilocybe Mexicana and Psilocybe Cyanescens so a person needs only a very small amount.

 

 

Are the exotics more difficult to grow? Are they more picky about their conditions, and do they require more knowledge and skill?

 

Most people probably wouldn't believe it, but the mushrooms cure or treat all kinds of things. Look up their effects on cluster headaches. These are headaches so bad, that a perfectly normal, sane person will sometimes commit suicide just to escape the pain. The mushrooms vanquish the headaches.


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#6 Heirloom

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Posted 17 November 2017 - 10:16 PM

benny they are just more potent so I don't have to eat as much, not much different than growing any other mushroom.

I believe mushrooms heal, I hear it from lots of people

#7 tuftygrasses

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Posted 18 November 2017 - 01:59 AM

I went to the lecture about this that is touring the UK. Nice man that Dr. I hope to see his trip integration therapy groups popping up more. 

He said that the inital dose was 10mg and then 25mg of I think psylocibin. I was wondering how many grams of cube that equated to but people where asking much fancier questions :) 



#8 Jeepster

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Posted 18 November 2017 - 08:38 AM

Fungus has made my depression and PTSD quite manageable, Ayahuasca has made them virtually nonexistent.

My apologies to the folks above, I am out of 'likes' yet again.

Edited by Jeepster, 18 November 2017 - 08:40 AM.


#9 Alder Logs

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Posted 18 November 2017 - 12:23 PM

Depression and my PTSD became not much of an issue when I saw it as coming out of my stories alone, as real as they seemed, banked in some pretty dramatic memories as they were.   The body that is centered on this particular expression of life still has this old ADHD brain, and I am in an experiment to see if microdosing has anything for helping make the attention more stable.   Don't even know if I would like that, but still would like to try it. 



#10 bennylava

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Posted 18 November 2017 - 12:40 PM

I too will experiment with microdosing eventually. I still need to do more testing for myself, but at this point, for me it looks like its going to be more like "small dosing". And not "micro" dosing. What is considered a micro dose anyway?

 

It would be really cool to see a comprehensive list of all the things that mushrooms are known to treat/heal/cure. So far I've heard all kinds of things. PTSD, depression, general spiritual malaise, cluster headaches, being a woefully selfish douche, on and on. Maybe "general personality disorders" would be a good description for part of what it treats. If the list actually went into detail on all the official psychiatric terms that the mushrooms will treat, I suspect the list would be quite long. And that some of these mental issues would get left out just because we still don't actually know every last little thing that they can help you with. An episode of Futurama comes to mind: Scientists are classifying this as "a miracle".



#11 Alder Logs

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Posted 18 November 2017 - 12:54 PM

I suspect there will be help both in psychological and physiological spheres.   A clearer seeing helps take care of psychological issues, and even a slight rewiring of the physical, within the neural-networks, neurons, and neurochemical environments, improvement is in the realm of possibility with this as medicine.  Maybe it's the wiring between brain and heart?

 

http://noeticsi.com/...-brain-science/


Edited by Alder Logs, 18 November 2017 - 06:45 PM.

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