I just listened to a wonderful interview with Michael Pollan, who just published a book entitled How to Change your Mind. The interviewer is Sam Harris, who, I am aware, is disliked (for good reasons) by many. He is, though, a skilled, thoughtful interviewer.
Mr. Pollan touches on 5-Meo-DMT, LSD, and marijuana, but the main topic of discussion is psilocybin. He discusses temporary ego dissolution as a likely experience for most, and how this can especially benefit those who are facing their own imminent mortality due to cancer. He then laments the reason (admitting defeat) that most oncologists are so reluctant to recommend such to their dying patients.
The brain's default mode network is also explained here in a way that is understandable to anyone, regardless of background.