From a mental standpoint, the thought of 'the big one' bothered me some when I was living just outside of Hammond Oregon, right at the mouth of the Columbia river. I was in an RV park right on the river bank, and when the big quake does hit, the bridges that you have to go over to get out of that tsunami zone will likely have been compromised.
That entire area will be scoured clean by a large tsunami (so will the Long Beach Peninsula to the North), and if its caused by a big quake from the cascadia subduction zone, there will be no time for emergency aid to help evacuate before it happens. I don't see the possibility of any survivors from that little NW corner of Oregon. There are no hills to climb, and if the bridges are out its just a waiting game.
So what did I do? I moved to one of the most seismically active parts of the planet, within sight of two active volcanoes, lol. I don't lose any of sleep over worrying about it, what will be, will be.