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Microdosing Psilocybin and Tricyclic AD's?


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#1 Cuboid

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Posted 27 December 2018 - 02:37 PM

Has anyone used Psilocybin whilst being treated with a tricyclic antidepressant?
From what I've read so far I gather it can potentiate the Psilocybin but I haven't found anything definitive regarding safety issues.
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#2 WeKnow

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Posted 01 January 2019 - 04:27 PM

I know several people who do it and I suspect it just makes the benefits less pronounced. I'd be interested to learn about this too.



#3 MycoBabe

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Posted 30 January 2019 - 10:02 PM

idk what kind of med I am on now, but I can definately tell you that my past psych meds did... It covered or blocked everything...and usually if i dose to check a strain, if it gets to be too mcuh, I can take a klonapin , and it kils it all 



#4 Cuboid

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Posted 06 February 2019 - 03:52 PM

I know several people who do it and I suspect it just makes the benefits less pronounced. I'd be interested to learn about this too.


It seems quite well documented that the SSRI type of antidepressants reduce the effects of psilocybin but I haven't found much on the interaction of trycyclic antidepressants and psilocybin other than one or two mentions of it increasing the effects of the psychedelic.

#5 Cuboid

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Posted 06 February 2019 - 03:54 PM

idk what kind of med I am on now, but I can definately tell you that my past psych meds did... It covered or blocked everything...and usually if i dose to check a strain, if it gets to be too mcuh, I can take a klonapin , and it kils it all

See above post re: SSRI's blocking/reducing effects.

Klonopin (clonazepam) is a benzodiazepine.

#6 Cuboid

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Posted 06 February 2019 - 03:57 PM

Anyone got any info on TRICYCLIC antidepressants and psilocybin?

Can anyone suggest a more appropriate sub board of Mycotopia for this topic? I suppose my question isn't microdosing specific.

Edited by Cuboid, 06 February 2019 - 03:57 PM.


#7 Cuboid

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Posted 18 March 2019 - 01:44 PM

Cautious guinea pig here. I've taken about 0.25g dry cubensis each day for last few days, aiming to get into habit of 5 days on 2 days off cycle.
My head hasn't exploded or anything so in terms of interaction with the Tricyclic meds it seems so far so good.




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