Wrote this up in an older topic, but convinced that it is too long and hard to read, so decided to condense into a few pages with references this time, so easier to understand.
This is simply some info you won't easily find...as this was discovered when reviewing the 2011 Thomas S Ray Receptorome study, and putting all the values into chart form. Even most academic and scholars don't seem to be aware of the recently published receptorome data for DMT from Thomas S. Ray's study, and it's comparison with the other natural psychedelics.
DMT lacks anti-serotonin properties. (Ref 1 & Ref 4)
What does this mean? That is for you to decide. Perhaps something or nothing. Just writing up a comparison with the other natural psychedelics to gain a better understanding of the science & overall picture. Comments are welcome. Just showing that dmt on it's own may have different properites and effects then when it is "married" (Ayahuasca terminology) with components of traditional Amazonian snuff's or Caapi (ie) dreamed as an admixture.
Caapi's 2nd largest beta carboline alkaloid: Tetrahydroharmine (THH) appears to play an important role in blocking serotonin which happens when 5-ht1a is agonized, as dmt does not do this by itself, but requires either caapi or components of Amazonian snuff to do this, ie teamwork. THH also agonizes all 3 adrenal receptors (a2a, a2b, and a2c).
2011 Thomas S. Ray study: Breadth of Receptor Binding, 4.00=max, 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00
(these serotonin filters/gates/barriers/doors make up >80% of brain 5-ht & are broken down when 5-ht1a is agonized)
Real life examples that occur when serotonin filters are broken down at 5-ht1a AND the psychedelic molecule works in the place of serotonin at the other 20% of brain 5-ht (everything that is not 5-ht1a): music sounds better, infinite beauty is easily perceived, feelings of universal eternal Love, spiritual things and qualities take on a significance that is utterly stupefying, etc.
Dmt by itself has been found in the Receptorome study to not block serotonin...while the following traditional team players have been found to strongly block serotonin: 5-ho-dmt in Amazonian snuffs, 5-meo-dmt in Amazonian snuffs and the 2nd largest alkaloid in caapi (thh or tetrahydroharmine). All 3 are thus anti-serotonin, and surprise: traditional.
Serotonin blocking is a main effect of all the natural oral entheogens like the semi-synthetic LSD, mescaline, Ayahuasca, mushrooms, 5-meo-dmt & bufotenine (found in snuffs). See 2011 receptorome chart below.
Ibogaine inhibits both serotonin and dopamine reuptake transporters (it is an SDRI or serotonin & dopamine reuptake inhibitor). (Ref 6)
New discovery: the recently discovered adrenoglomerulotropine (a hormone of the pineal gland, otherwise known as 6-Methoxytetrahydroharman) (Ref 2) is an isomer of tetrahydroharmine, found in caapi. Caapi was said by the Indians to have Telepathine qualities as Ayahuasca was said to facilitate telepathic communication among tribal members.
DMT is super potent at the other 20% of brain 5-ht receptor sites, way exceeding even psilocin (see chart below), but in doing so, it must give up 5-ht1a binding, (serotonin blocking) which makes up over 80% of brain 5-ht, so when you combine admixture with components of Amazonian snuff's or caapi you get a "team action".
LSD scientist & founder of Heffter Institute Dr. Nichols:
LSD has very strong potency in blocking the action of serotonin. The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist. (Ref 7)
5-ht1a makes up >80% of brain 5-ht...5-ht1a agonism blocks serotonin. (Ref 3)
Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
Breadth of Receptor Binding, 4.00=max, 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)
As we go thru day to day life, the brain serotonin filters (or gates) are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". (Ref 5) He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world". 5-ht1a inhibition while the psychedelic molecule works in the place of serotonin at the other 20% of brain 5-ht theoretically causes this filter system to be lifted, and the infinite mind to manifest in combination with dmt for example.
Technical analysis with help from Ray's study: these molecules can only "do so much" on their own, as the docking size of the molecule to the receptor is like a key fits a hole. Example: LSD is super potent at almost all the brain 5-ht receptors thanks to it's large molecular size, but it must give up binding strength at adrenal sites a2b and a2c so that it can still hit 80% of brain 5-ht at 5-h1a with great strength.
Mescaline is the world's strongest adrenal a2c agonist (off the charts strong with 4.00 at a2c). This helps to explain how mescaline is more aesthetic and primal compared to the more analytical LSD, which lacks a bit aesthetically. Unlike what Wikipedia states, mescaline has no activity at 5-ht2a.
5-meo-dmt is off the charts strong with 4.00 at 5-ht1a, and can easily obliterate or shatter the ego into a million pieces even at the tiniest of doses due to it's extreme strength at over 80% of brain 5-ht (5-ht1a).
Additional 1988 study which backs up the 2011 Thomas S. Ray receptorome study:
Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. https://www.ncbi.nlm...pubmed/2828913
5-HT1A agonist: All the tryptamine derivatives substituted in position 5 of the indol were potent agonists [5-HT, 5-CT, 5-MeO-N,N-DMT, 5-methoxytryptamine, and bufotenine (5-ho-DMT),
whereas tryptamine, N-methyltryptamine (NMT), and N,N-dimethyltryptamine (DMT) were very poor agonists.
N-Methyltryptamine (NMT) found in barks: https://en.wikipedia...thyltryptamine
Real life example: Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":
DMT + tiny amounts of 5-meo-dmt (from Oroc's book):
As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.
With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.
Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.
This experience leads to the interesting question of selectively combining DMT and 5-MeO-DMT for a more visionary and somewhat less overwhelmingly transcendental experience. (Or for the other way around). This combining of the two endogenous entheogens is being tested in changa blends (reportedly at a 90% DMT to 10% 5-MeO-DMT ratio), while many Pharmahuasca urban-shamans are also adding 5-MeO-DMT to their ayahuasca-analogues to transform and deepen that experience. It seems likely to me that the combining of DMT and 5-MeO-DMT in various ratios and manners will only become more popular as the exponentially increasing number of psychonauts search for new psychological terrain to explore.
Another example below is a 45 minute visual session report from Benny Shannon with Ayahuasca. I found it inspirational and a good description of an Ayahuasca journey:
From Page 138 of "Antipodes of the Mind":
By way of conclusion, I present two additional examples. Unlike all other examples in this chapter, which consist of specific visualizations pertaining to specific content items, these examples are records of sessions. They cite or summarize the various visualizations experienced by one individual drinker in one setting. I bring them in order to give the reader a more direct feel of the visionary experience induced by Ayahuasca.
The first example consists of a 'real-time' verbatim report of what I saw in one session in which I partook of Ayahuasca by myself. I spoke aloud describing what I was seeing and notes were taken by the person who watched me. This session is not part of the core corpus and it is the only session of which I have such a recording. Overall, I would characterize this session as one of moderate strength. In it, there were no grand visions and most of the visualizations in it are snapshots and relatively simple scenes. Furthermore, in this session I had very few ideations and no special psychological insights or spiritual experiences whatsoever.
Yet, I find this report to be especially valuable in portraying the general flavour of Ayahuasca visions. Manifest in it is a fairy tale-like ambience and an overall air of magnificence and enchantment. Also featuring in the report are several details that are characteristic of Ayahuasca visions in general—these include fire (note the various ways it is incorporated within the narrative of the vision), light-producing objects, carriages, and processions. Also recurrent in the report are turning movements, upward movements, and looking forward far into the distance. One comment made by a person seen in this visual sequence is a good example of how ideas relate to Ayahuasca visualizations. The entire sequence lasted about forty minutes:
A golden crystal chalice.
Flowers. In the flowers there are birds and insects and the birds go up and up.
A wheel is turning and there is a rod that is turning round and round. From it, a fire ignites.
An old man holds a taper and from it the fire climbs up and up.
A futuristic city.
A Chinese king is sitting and turning his parasol. Now he is in his study. In the background, birds are kissing one another.
A great hall—like an animated movie.
There is a code here—like that of Morse or the genetic code. The code is constituted by many, many dots, the density between which varies. All this is a language calling to be deciphered.
There is something that pushes up and up. It is like a mountain train. All the time it goes up and up.
A car from the 1920s. Delightfully magnificent. From it emerge light and flowers. Advancing with this light, we pass along gold-plated walls and come out through a staircase made out of gold and ivory. The steps go up and down and reach a theatre.
Up in the heavens there is a woman escorted by a man. In the woman's hand there is a torch that swirls. Lights come out of it in the form of flags and the flags turn into hats full of gems. The gems are sparkling.
A scene in Europe in the sixteenth or perhaps the eighteenth century. Knights are riding. They are mounted upon magic motorcycles full of colours and light. All is like a cartoon and enchanted. It is all part of big procession. There are also small dwarfs there. Two of them are holding a banner with the insignia of the sovereign.
An Indian is smoking a big pipe. Through an old telescope, a man is peering into the far reaches of the universe. A view of the planet Earth turning round and round.
Beautiful gardens like Versailles and the Tuilleries.
There are ballerinas there. Like a cabaret. Their thighs are exposed. One woman gets to the balustrade and is watching the audience.
The Indian is smiling. The message is that 'all of these are the expressions of the same source, a source of bounty and grace'.
In a King's reception hall. There are chalices full of wine. Long processions of carriages proceed further and further. Slowly, all the time, the horsemen are pushing forward. In the hall, the seats are made out of silver. There is a feast. A big pot is placed in the middle. A fruit salad is offered in goblets of finely polished, very clear glass. Slowly, the chef pours some sort of syrup or gooey topping. The sauce covers the fruit and then it ascends upwards.
An elephant lifts up its trunk high and looks far, far forward. Up there are birds and they are looking in my direction. There are flowers, and butterflies are flying from flower to flower. All are washed in the light of the sun.
Women are dancing. Carriages come one after the other and the wine flows. An officer approaches a carriage and salutes. The footman bows and opens the carriage's door. The Queen is stepping out."
The second example was provided by a young man who partook of Ayahuasca in private sessions conducted in Europe. This individual is not amongst the informants whose data are analysed in this book; his report was communicated to me just when the typeset of this monograph was being sent to the publisher. I present this report as an illustrative example of the experiences of a first-timer. The following is a slightly edited synopsis of what this person saw during his first two sessions with the brew. I shall note that while the report is rich in details, the intoxication experienced was not especially strong; by the present structural typology, all items seen would be characterized as single, simple images.
Animals. Those seen most frequently were serpents, felines, and birds. Some of the serpents were ornate, like Chinese dragons; the felines included tigers and black pumas; the birds included parrots, peacocks, and toucans. Also seen were a galloping horse, dragons, monsters of all sorts, and evil beasts; with some of the latter blood was associated.
Many human persons were seen. Amongst these were Indians and a sensuous Caribbean dancer. A person present in the session appeared to have the face of a gorilla with the beak of a bird.
Palaces and mansions. Amongst the buildings seen were skyscrapers and pyramids. Also seen were interior decorations of buildings. These were very exquisitely ornamented; many were gilded.
Cities. Many different ones were seen; some had futuristic architecture.
Landscapes. These included forests, open deserts, river scenes, and scenes under water. Associated with the latter were corals and 'tornadoes offish'. Overall, the landscapes had an ambience of serenity and silence.
Especially frequent were disembodied eyes; many of these pertained to big cats. Other items noted: an Indian in a boat, an old woman turning white and transforming into a young girl, cars of the 1950s that were colourfully painted in a style which was 'rather kitsch', streams of gold.
The trees outside looked like goddesses.
Shanon "Significantly, the items reported by this informant include all those that are typical of Ayahuasca visions. As such, this report, I find, is a good example supporting the cultural non-specificity of these visions."
Highly recommend reading "Antipodes of the Mind" by Shanon, as I concur with the same content & style of visions seen by not only Shanon but the 300 other interviewed in his book.
Example 1: was shown an overhead view of the lost city of Atlantis, zoomed in for a bird's eye view of the entire complex (it really existed).
Example 2: another vision: flew over what looked like Los Angles, as I had a bird's eye view of all the homes and swimming pools below, this went on for at least 1 to 2 minutes, absolutely breathtaking.
Example 3: was taken on a tour of a distant island's tiki's...as a young beautiful native island girl waved her hand to show me that these tikis marked the boundaries of their sacred spaces.
Example 4: have seen the most beautiful naked female forms (like a comic) with dazzling detail, color, and breath taking beauty, exceeds anything an artist could ever paint. Caapi + hawaiian psychotria is the bomb. Peace out.
(1) Ray, Thomas S. "Psychedelics and the Human Receptorome", Feb 2 2010, PLOS one research article.
(2) Naranjo, Claudio. "Psychotropic Properties of the Harmala Alkaloids", Ethnopharmacologic search for psychoactive drugs, Jan 28-30, 1967.
(3) Nichols, Charles D. "Serotonin Receptor Signaling and Hallucinogenic Drug Action", The Heffter Review of Psychedelic Research, Volume 2, 2001.
(4) Dumuis, Sebben, Bocaert. "Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture", Molecular Pharmacology, Feb 1988; 33(2):178-86.
(5) Goodman Ph.D, Neil. "The Serotonergic System and Mysticism", 2002.
(6) Bulling, Schicker, Zhang, Steinkellner, Stockner, Gruber, Boehm, Freissmuth, Rudnick, Sitte, Sandtner, "The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters", J Biol Chem. 2012 May 25; 287(22): 18524-18534.
(7) Nichols Ph.D, David. "LSD and it's Lysergamide Cousins", The Heffter Review of Psychedelic Research. 2001;2:80-87.