Jump to content


A systematic study of microdosing psychedelics

  • Please log in to reply
1 reply to this topic

#1 Cuboid



  • Free Member
  • 770 posts

Posted 06 February 2019 - 03:47 PM

A systematic study of microdosing psychedelics

Vince Polito, Richard J. Stevenson


The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and wellbeing benefits. There have been no published empirical studies of microdosing and the current legal and bureaucratic climate makes direct empirical investigation of the effects of psychedelics difficult. In Study One we conducted a systematic, observational investigation of individuals who microdose. We tracked the experiences of 98 microdosing participants, who provided daily ratings of psychological functioning over a six week period. 63 of these additionally completed a battery of psychometric measures tapping mood, attention, wellbeing, mystical experiences, personality, creativity, and sense of agency, at baseline and at completion of the study. Analyses of daily ratings revealed a general increase in reported psychological functioning across all measures on dosing days but limited evidence of residual effects on following days. Analyses of pre and post study measures revealed reductions in reported levels of depression and stress; lower levels of distractibility; increased absorption; and increased neuroticism. To better understand these findings, in Study Two we investigated pre-existing beliefs and expectations about the effects of microdosing in a sample of 263 naïve and experienced microdosers, so as to gauge expectancy bias. All participants believed that microdosing would have large and wide-ranging benefits in contrast to the limited outcomes reported by actual microdosers. Notably, the effects believed most likely to change were unrelated to the observed pattern of reported outcomes. The current results suggest that dose controlled empirical research on the impacts of microdosing on mental health and attentional capabilities are needed.

Citation: Polito V, Stevenson RJ (2019) A systematic study of microdosing psychedelics. PLoS ONE 14(2): e0211023. doi:10.1371/journal.pone.0211023

Editor: Danilo Arnone, King's College London, UNITED KINGDOM

Received: March 28, 2018; Accepted: December 10, 2018; Published: February 6, 2019

Copyright: © 2019 Polito, Stevenson. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Full article:-

Edited by Cuboid, 06 February 2019 - 03:49 PM.

  • Buitensporig and CourageToGrow like this

#2 PsyBearknot



  • Moderator
  • 5,437 posts

Awards Bar:

Posted 10 February 2019 - 05:47 AM

Nice. Book marking for later reading

Like Mycotopia? Become a member today!