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Identification of ω‐N‐Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product


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#1 PistolPete13

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Posted 13 March 2019 - 12:35 AM

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We report the identification of ω-N-methyl-4-hydroxytryptamine (norpsilocin, 1) from the carpophores of the hallucinogenic mushroom Psilocybe cubensis. The structure was elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry. Norpsilocin has not previously been reported as a natural product. It likely represents the actual psychotropic agent liberated from its 4-phosphate ester derivative, the known natural product baeocystin. We further present a simple and artifact-free extraction method that prevents dephosphorylation and therefore helps reflect the naturally occurring metabolic profile of Psilocybe mushrooms in subsequent analyses.

Attached File  lenz2017.pdf   746.91KB   35 downloads


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#2 CatsAndBats

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Posted 13 March 2019 - 06:50 PM

Wow, nice find.


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#3 roc

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Posted 13 March 2019 - 08:35 PM

Sweet!


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#4 Mushinist

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Posted 13 March 2019 - 08:59 PM

Pistol always finds some good reading material!

Thanks for sharing!

Edited by Mushinist, 13 March 2019 - 09:00 PM.

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