We are aware that there is individual variation in sensitivity to psychedelics (psilocybin) in the microdosing range. Part of the problem with confirming or quantifying this variation is a lack of objective measurement of drug effect.
I have observed a psychedelic naive individual with considerable experience in meditation and a healthy non-drinker on no other medications at all. They had no perceivable effect from what might be considered a typical or perhaps 2x microdose. Confirmation of potency and proper dosing was observed from this known good and 'new' batch of properly prepared cubensis. The dose was 0.25 gm fasting.
Another trial will be done, next with 0.5 gm with the same individual.
Has anyone noted a change in effective dose in such individuals? This is only a study of '1' but while I await further testing, I wanted to stir up some conversation. I would consider 'no perceived effect' of 0.25 gm on an empty stomach to be a quite unexpected.