Jump to content


Microdosing with tricyclic and atypical antidepressants

  • Please log in to reply
2 replies to this topic

#1 CentralLimit



  • Free Member
  • 27 posts

Posted 17 February 2020 - 09:58 AM



I wonder if you can check two assumptions of mine regarding microdosing shrooms. 


I am taking two meds for managing remnants of severe depression.

  • Wellbutrin (generic is Bupropion, atypical antidepressant, 400mg/d)
  • Pamelor (generic is Nortriptyline, tricyclic antidepressant, 125mg/d)

From my research, microdosing has a decent chance of helping my mood swings, which are managable, but still disruptive.  That's why I am on Mycotopia, rather than for macrodosing for learning and self healing, although those really interest me too.


I microdosed 0.2g dried Golden Teacher for a month, 1 day on, 2 days off (Fadiman protocol).  I think I saw results, my wife swears she did too.  There were never any perceptible effects, like brighter colors, hallucinations, "overt" brightening of mood.  Considering the lack of effects, I wondered if I was taking the right dose, so, I took 0.5-0.6g a few times, with no effects either. 


So, my first assumption is that my meds are blocking any tripping, or any overt effects.  From what I read, it is probably the Pamelor, since Welbutrin does not interact with serotonin receptors, and Pamelor, while not a SSRI or SNRI, has some interactions with serotonin receptors.  I wonder if this sounds reasonable to Mycotopia.  I mean, I think I should have felt something at 0.6g, right?


In light of this, I began researching if antidepressants block any and all effects of microdosing.  I didn't find much info in the OMC regarding this.  My second assumption is that despite no overt effects, I would probably still see benefit from microdosing at a reasonable level, like 0.2g, following some protocol, such as Fadiman's or Stamets'.  I wonder if Mycotopia would agree with the concept, or, if you guys have seen this, and microdosing is not going to provide benefits at all.  I mean, I think there is more to shrooms than just just binding with serotonin receptors, but, I am not really sure,



Thank you for the help.

  • PCaddict likes this

#2 CentralLimit



  • Free Member
  • 27 posts

Posted 25 February 2020 - 07:14 PM

Bump for justice. 


Don't let the terrorists win. 



EDIT: Actually, I just came across a name for what I was searching for:  The Entourage Effect.




My thanks to Tenderfoot for creating the "mushroom nasal spray" post.


(sorry I don't know how to credit him and link the post properly).

Edited by CentralLimit, 25 February 2020 - 07:48 PM.

  • PCaddict likes this

#3 raymycoto



  • Gold VIP
  • 618 posts

Awards Bar:

Posted 18 May 2020 - 02:16 AM

I don't have time to go into detail on this but let me say that without a doubt, both of those meds reduce the effectiveness of 5HT2A agonists, AKA psychedelics. I'll try and get back with more info. It is primarily the Wellbutrin. SSRI, SNRI are bad drugs. More on that later. I have seen individuals who had to take over a gram to barely get a microdose effect. I have worked with many individuals in getting them off these meds. There is a sort of myth circulating that SSRI should boost or possibly cause some sort of serotonin overdose and to beware of a serotonin storm. It is the opposite. Your brain gets so awash in serotonin it cannot respond to the psychedelic dose as an SSRI naive brain would respond and that is the nature of the entheogen insensitivity IMO. 


I have to give the disclaimer that I'm not offering any recommendation or medical advice based on your limited description. I would need more information to make a responsible recommendation and formulate a plan for wellness sans such drugs when presented with an individual already on them. 


I'm just saying that I suspect that I would, in a similar individual presenting with the same history, offer the advice to rather quickly taper both meds to zero with assistance of some non-psychoactive pharmaceuticals while testing weekly microdoses of entheogen. Being off these (SSRI, SNRI) in the proper context can feel so good that it may produce a far greater antidepressant effect. The original intent of Prosac, the prototypical SSRI in 1986 was to be used for less than 6 weeks and this is how any SSRI should be limited if used at all. 


I suggest you read Robert Whitacker - Anatomy of an epidemic or at least watch a video of his re SSRI use.


  • PCaddict likes this

Like Mycotopia? Become a member today!