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Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step


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#1 tregar

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Posted 31 July 2020 - 10:44 AM

To test the 1992 adducts study: LSD blotters can theoretically be converted at home into 1-acetaldehyde LSD or basically equivalent to what ALD-52 is in one step, see sample super highly visual & aesthetic reports in notes (16) and (17):
 
Dissolve LSD blotter(s) in 1 shot of cold sherry wine (contains 10mg acetaldehyde) with 5 drops of peppermint extract (contains 2 mg water soluble acetaldehyde & isovaleraldehyde & their corresponding acids) for 3 hours in fridge, with swirling once per hour. Researchers achieved 100% new adduct product in 1.5 hour. The sherry is already at ph=4, so no acidic solution needs to be made, like study calls for. They used a stir mantle in fridge, so recommend 3 hours sitting in fridge if not stirring, just hand swirl once an hour.
 
ALD-52 is know to be even more visual, conceptual & aesthetic compared to the more analytical and less aesthetic LSD, also more forgiving and relaxing mentally compared to LSD which produced brain waves associated with intense concentration & anxiety, reports from Sandoz labs.
 
Why is ALD-52 possibly more aesthetic than LSD? The adrenal receptors are hit heavily by natural entheogens like mescaline, Ayahuasca with caapi, shrooms, and are believed by some to be responsible for alot of the "aesthetics/euphoria/appreciation of beauty" feeling activity that is experienced while tripping. It is quite possible that ALD-52 agonizes all 3 of the adrenal receptors A2A, A2B, and A2C.
 
Mescaline for example binds to A2C with "off the chart" rating of 4.00 (max). Anyone who has ever dreamed cactus knows the appreciation for beauty is "thru the roof". See chart below.
 
LSD only agonizes adrenal A2A (as far as adrenal receptors, see chart below).
 
See last post #15 of "Potent LSH & penniclavine fresh from morning glory vine & relation to ancient Greece"
 
 
The Aztecs and Mayans were known to add the extract from morning glory seeds (same exact alkaloid profile as the Greek claviceps paspali) to a drink containing alcohol (note 2). We know that sherry wine contains average 10mg acetaldehyde per 30ml or shot glass. The Aztecs and Mayans apparently knew about the acetaldehyde adducting properties of wine and alcohol, which as shown in the 1992 adducts study (note 6) will cause acetaldehyde to adduct onto the bottom NH group on the indole of LSH and penniclavine forming something more akin to looking like ALD-52, (at least bottom indole wise).
 
The table from Sandoz suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state. Sample ALD-52 trip reports given in (note 16) and (note 17).
 
LSA (C16 H17 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSA
LSH (C18 H21 N3 O) + acetaldehyde (C2 H4 O) at bottom indole NH group = 1-acetaldehyde LSH
LSD (C20 H25 N3 O) + acetal (C2 H3 O) at bottom indole NH group = 1-acetal LSD (C22 H27 N3 O2) or ALD-52
 
2016 Polish morning glory study found 3x higher amounts of LSH in MG seeds direct from grower/producer vs retail (note 7):
fresh black seeds from vine: likely 5.00 LSH to 5.00 penniclavine ratio
seeds direct from growers: 1.71 LSH to 5.08 penniclavine ratio
seeds off retail racks: 0.54 LSH to 4.75 penniclavine ratio
 
Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37).
 
Note (6) from post #2 of above link: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed at bottom of this post ---> ie before (page 8439) and after (page 8441).
 
The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution."
 
Note (15) Breakdown of water soluble acetaldehyde & isovaleraldehyde (and their corresponding acids) in peppermint extract: 1mg standard is equivalent to .001ml, 5 drops used in recipe = .25ml, .25ml = 250mg identified compounds, alcohol percent of peppermint extract = 91% alcohol so then 250mg x 0.9% = 23mg leftover of compounds, assuming 9% of this is the acetaldehyde/isovaleraldehyde & their corresponding acids, [see paper "Chemical Composition and Biological Activities of Mentha Species by Brahmi"] then approximately 2mg exists in 5 drops.
 
Note (16) Sample ALD-52 trip report #1:
 
"Had the chance in dreams to try ALD-52 around 10 years ago twice, and the blotter had diagrams of the ALD-52 molecule on the back of the blotter, and both times found the 300ug trips experienced in dreams to be PROFOUNDLY VISUAL, remember looking at a living woman's face and seeing it covered & overlayed with colored hieroglyphic symbols. The trip was very strong visually and yet found it relaxed and potently humorous, laughed for at least an hour watching episodes of "Funny or die" at the time.
 
Also remember seeing a group of Indian Shaman's sitting in a circle floating in mid-air when I walked into the bedroom, potent visuals...miss ALD-52, but the recipe above will transform the morning glory seed's LSH and LSA into similar molecules at least at the bottom indole NH group, which helps significantly in achieving a visually strong trip, sounds are amplified and music heavenly, strong audio heightening qualities, euphoric & stimulating yet relaxed journeys.
 
Anything longer than around the length of an acetaldehyde molecule (C2 H4 O) attached at the NH indole of the ergoline LSD molecule (especially 1-p-LSD, propionyl = C3 H5 O) may not fit properly into the very specific receptor binding site (as ALD-52 fits, acetyl = C2 H3 O), so cinnamaledehyde (C9 H8 O) and similar very long structures may not have a chance of docking into the receptor site properly."
 
Note (17) Sample ALD-52 trip report #2:
 
hxxps://www.reddit.com/r/LSD/comments/4yn8ou/highly_underestimated_ald52/
 
"Yes, I realize it's not technically LSD but really, it might as well be. I took 300ug thinking it would be mild if anything. Granted it wasn't as intense mentally as LSD can sometimes be, but conceptually and aesthetically it is beautiful beyond anything I ever anticipated. I feel perfect. At one. Better than I've felt in so long. I thought I could never trip again on anything but this is honestly paradigm changing for me. ALD-52 should be considered just as powerful as LSD-25 although it's a lot more relaxed and somewhat forgiving. As it is probably apparent I'm still very deep into this experience and I hope this to be an open discussion to anyone who would like to be involved.
 
My god, I just went through multiple ego death experiences beyond anything I've ever experienced from LSD before. There are no words. I mean there are plenty of "words" but none of them mean a single thing compared to any of THAT. Dear GOD. I never expected anything like this, but I sure as hell needed it. Even if I'm the only one here to express it to, as that's realistically the truth of nature anyhow. However, anyone who felt compelled to actually read through all this insanity, I just want you to know you're beautiful and you are everything. All things are right and they always will be.
 
Anyway, as far as the ALD-52, I took 300ug as I said. It was amazing and stronger than I expected, however I don't think 100ug would be very eventful to be perfectly honest. If you're concerned about it being too strong 200 might be worth it but 300 was really a great amount if you ask me. Even if you haven't taken any lysergamides before ALD-52 is rather calm compared to LSD or even mushrooms for the most part. Visually though, at least for me, it was absolutely breathtaking. Colors and textures were shifting like crazy.
 
Everything was alive and magical. Patterns were forming everywhere. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically automatic and I reached that point multiple times. The first time I ever experienced ego death on LSD it left me with this beautiful feeling, like a deep inner glow that lasted for months afterwards. It eventually faded and I hadn't felt anything quite like it in years, but ALD-52 brought it back, and I feel like I've awakened from a spiritual coma.
 
Another thing is LSD sometimes causes my mind to wander uncontrollably unless I take my own initiative to focus, especially during the come up which can also sometimes fill me with restless confusion. Once I peak everything usually evens out, but ALD-52 put me in a state of perfect clarity from beginning to end. The come up was so smooth and comfortable.
 
I didn't notice the come down because I actually went to sleep when I felt like it was time to do so, which was an interesting surprise. Every time I've taken LSD I've had to let it run its entire course before even attempting to sleep. Often I would have to stay up for the entire day after which is obviously physically and mentally exhausting. But once I felt like the ALD-52 had made its point I went to sleep just like any other day, and woke up the next morning fully rested and mentally clear.
 
Overall, it felt very natural and I never had a single moment of uncomfortability or confusion. Just pure psychedelic bliss. I mean, I've had some amazing and extremely important experiences on LSD but honestly after the other night, think I prefer ALD-52. It felt like tripping for the first time again."
 
Note (27) Thomas S. Ray, Psychedelics and the Human Receptorome (2010):
hxxp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009019
Breadth of Receptor Binding, 4.00=max (off the charts), 0.00=min
LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61, 5-meo-DMT: = 4.00 (make up >80% of brain 5-ht)
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00, 5-meo-DMT: = 2.41
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00, 5-meo-DMT: = 3.48
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16, 5-meo-DMT: = 1.72
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00, 5-meo-DMT: = 0.98
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97, 5-meo-DMT: = 0.69 (sensual & entactogenic)
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00, 5-meo-DMT: = 1.55
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00, 5-meo-DMT: = 1.84
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 2.73
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00, 5-meo-DMT: = 3.69 (novelty, newness)
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00, 5-meo-DMT: = 2.38
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92, 5-meo-DMT: = 0.00 (aesthetic/beauty adrenal a2a)
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00, 5-meo-DMT: = 0.86 (aesthetic/beauty adrenal a2b)
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00, 5-meo-DMT: = 1.57 (aesthetic/beauty adrenal a2c)
Explanation of 5-ht1a receptors:
 
As we go thru day to day life, the 5-ht1a brain serotonin filters (gates, or day to day survival filters as I like to call them) which make up over 80% of brain 5-ht are in place so that we will not be overwhelmed by the perception of the way things would appear to an un-filtered mind, or "Mind at Large" as Aldous Huxley describes it in "Doors of Perception" as "infinite or eternal". He also referred to the visions as coming from "the other world" in his book "Moksha". I prefer to think of it in similar terms as well "the spirit world" or "the other world". Huxley referred to normal day to day mind state as the "reducing valve" due to it's filtering.
 
5-ht1a inhibition by entheogens (in green above) theoretically cause this filter system to be lifted, and the infinite mind to manifest in combination with oral dmt from traditional psychotria for example with the caapi and/or harmalas providing the 5-ht1a inhibition, just as bufotenine in snuff's provide the 5-ht1a inhibition combined with the dmt in the snuff's, resulting in a 3 hour experience ie both examples of Teamwork on how these entheogens are used traditionally in the Amazon.
 
Thomas S. Ray's study shows a value of 3.57 at SERT for Ibogaine (4.00 is max). Ibogaine has been shown to inhibit serotonin transporter (SERT) noncompetitively, in contrast to all other known inhibitors, which are competitive with substrate. Ibogaine inhibits both serotonin and dopamine reuptake transporters, it is an SDRI or serotonin & dopamine reuptake inhibitor. Tetrahydroharmine (THH) is a serotonin reuptake inhibitor, it is an SRI found in caapi. In other words, both are strong serotonin reuptake inhibitors which inhibit over 80% of brain 5-ht at 5-ht1a.
 
Dr. Nichols (LSD scientist): "LSD has very strong potency in blocking the action of serotonin. The morpholide lysergamide cousin had only about 1/10th the potency in blocking serotonin. Of the 5 diferent dialkylamides we studied LSD was the most potent and specific serotonin antagonist."
 
Dr. Nichols "5-ht1a makes up >80% of brain 5-ht...5-ht1a agonism blocks serotonin."
 
Serotonin blocking is a main effect of all the natural oral entheogens like the semi-synthetic LSD, mescaline, Ayahuasca, mushrooms, 5-meo-dmt & bufotenine (found in snuffs). See 2011 receptorome chart above. Ibogaine inhibits both serotonin and dopamine reuptake transporters (it is an SDRI or serotonin & dopamine reuptake inhibitor).
 
An example of the importance of adding the serotonin reuptake inhibition properties of 5-meo-dmt for example to dmt (which totally lacks 5-ht1 reuptake properites on it's own) is shown below. This is the same way the snuff's are used in the amazon, as they naturally combine dmt with additives which cause the reuptake of 5-ht like bufotenin for example, this results in a 3 hour experience from the snuff's.
 
Oroc's experiment of combining 5-meo-dmt with DMT sounds imho very much like a short beautiful transcendental Ayahuasca experience, from his book "Tryptamine Palace":
 
DMT + tiny amounts of 5-meo-dmt, perhaps similar theoretically to Amazonian snuffs which have a makeup of 7.4% bufotenin (potent 5-ht1a agonist), 0.04% 5-MeO-DMT (potent 5-ht1a agonist) & 0.16% DMT (zero potency as 5-ht1a agonist):
 
James Oroc "Tryptamine Palace":
As an experiment (and in a foreign land) I smoked the last of the Bufo alvarius venom (the story of whose collection is described within the pages of Tryptamine Palace) with some ‘regular’ DMT (extracted from Jurema Preta.). In the vast majority of my early nigerine (DMT) experiences, I encountered visual fields of ‘dots’ that would come together to form images, much like the pointillism style of painting developed by Georges Seurat or the Australian Aboriginal song-line paintings.
 
With the addition of the 5-MeO-DMT containing toad-venom to the DMT however, the visual characteristic was completely different and totally unique to my experiences so far. On this occasion there was a complete lack of ‘dots’ or ‘points’ of any kind, the fine lines of the constantly changing imagery were like those painted with a single-hair brush on Tibetan thangkas and due to the overwhelming artistry of what I was seeing, I could only think of the vaulted ceiling of the Sistine Chapel in comparison.
 
Sistene Chapel: This was without a doubt the most ‘visionary’ experience I have ever been fortunate enough to encounter and I lay there with my eyes shut watching the most fantastic parade of the Collective Unconsciousness imaginable, wishing that it would never end, and as I sit here now I can not even describe one tiny corner of it, since every image in the multitude of imagery was in such constant motion that they defied all but a glimpse. And then moments later, like a tent collapsing when its ropes are cut, the vision is gone. Leaving only a struggle of words to explain it, since nothing before or after has come close to this experiences visual majesty.
 
This experience leads to the interesting question of selectively combining DMT and 5-MeO-DMT for a more visionary and somewhat less overwhelmingly transcendental experience. (Or for the other way around). This combining of the two endogenous entheogens is being tested in changa blends (reportedly at a 90% DMT to 10% 5-MeO-DMT ratio), while many Pharmahuasca urban-shamans are also adding 5-MeO-DMT to their ayahuasca-analogues to transform and deepen that experience. It seems likely to me that the combining of DMT and 5-MeO-DMT in various ratios and manners will only become more popular as the exponentially increasing number of psychonauts search for new psychological terrain to explore.

 

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#2 tregar

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Posted 31 July 2020 - 10:45 AM

Just happened to have been gifted 300ugs of extremely pure acid in dreams, dissolved in 1 shot glass full of Sherry wine with added 5 peppermint extract drops, sits in fridge 3 hours with swirling once per hour till consumed in dreams.
 
I know the effects of acid vs ALD-52 very well, and the two times I tried ALD-52 over 10 years ago, was astounded by the visuals, see my trip report in note (16) above. I also, like reporter in note (17) at the time found it to be more aesthetic, beautiful and relaxing than the more analytical and less aesthetic acid.
 
ALD-52 also has "double the anti-serotonin" power of LSD. Anti-serotonin means blockage of serotonin activity via 5-ht1a agonism, which in turn blocks the re-uptake of serotonin, see chart above.
 
Will report back tomorrow.
 
The priest at Eleusis added fresh mint (note 22) to their secret entheogenic brew believed to be composed of in theory ground up claviceps paspali infected paspalum distichum grass which grows adjacent to Eleusis in the famous Rharian plain.
 
Fresh claviceps paspali ergot contains the exact same alkaloid profile as the Aztec morning glory when fresh: sky high levels of LSH (lyseric acid hydroxyethylamide) and penniclavine. Animals became stimulated like with LSD when injected with penniclavine in 1958 [note 8]. Same with LSH, animals became stimulated like with LSD when injected with LSH in 1961 (note 9). As everyone knows, 2 drugs combined is more potent than just one.
 
Note [8] Ref (1) T. Yui and Y. Takeo, Japan J. Pharmacol. 7, 157 [1958].
 
Note (9) A. Glasser, Nature 189, 313 (1961)
 
Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.

Edited by tregar, 31 July 2020 - 05:11 PM.

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#3 PJammer24

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Posted 31 July 2020 - 01:21 PM

treger, do you have any idea what type of yield would be lost during the conversion from LSD25 to ALD52? I assume there is some type of loss during the reaction... I also don't know if dosage requirements for ALD52 are higher, similar to higher doses that are possible and sometimes needed when dealing with the purest LSD25...

 

LSD Dosage is pretty subjective and this may be a near impossible comparison to make. I have seen people heavily effected on a very small dose while others are eating hero doses of the same product..


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#4 tregar

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Posted 31 July 2020 - 01:49 PM

PJammer24 said:

 
tregar, do you have any idea what type of yield would be lost during the conversion from LSD25 to ALD52? I assume there is some type of loss during the reaction... I also don't know if dosage requirements for ALD52 are higher, similar to higher doses that are possible and sometimes needed when dealing with the purest LSD25...
 
LSD Dosage is pretty subjective and this may be a near impossible comparison to make. I have seen people heavily effected on a very small dose while others are eating hero doses of the same product..

No loss of product! You will retain all product with this easy process. 300ug of acid to convert to ALD-52 is a great dose, same dose I took in trip report note (16) above and other trip report in note (17) above from a different person. 



#5 PJammer24

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Posted 31 July 2020 - 02:37 PM

PJammer24 said:

 
tregar, do you have any idea what type of yield would be lost during the conversion from LSD25 to ALD52? I assume there is some type of loss during the reaction... I also don't know if dosage requirements for ALD52 are higher, similar to higher doses that are possible and sometimes needed when dealing with the purest LSD25...
 
LSD Dosage is pretty subjective and this may be a near impossible comparison to make. I have seen people heavily effected on a very small dose while others are eating hero doses of the same product..

No loss of product! You will retain all product with this easy process. 300ug of acid to convert to ALD-52 is a great dose, same dose I took in trip report note (16) above and other trip report in note (17) above from a different person. 

Right on... I would have suspected that dosage may differ or that the reaction would result in some type of loss... Good to know that dosage is comparable and that loss would be negligible if there is any at all... I am not a chemist and don't fully understand differences between specific reactions and how the materials are impacted by different reactions.


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#6 tregar

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Posted 31 July 2020 - 03:24 PM

I am tripping 300ug on this tonight, will report back tomorrow. Has been in fridge 3 hours with swirling once per hour. Ready to consume in dreams in 1 hour. 

 

https://www.friskyradio.com/


Edited by tregar, 31 July 2020 - 05:11 PM.

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#7 bezevo

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Posted 31 July 2020 - 04:16 PM

this  takes a bit to digest ..............but very interesting info

 

thanks


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#8 tregar

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Posted 31 July 2020 - 05:59 PM

2 hours into it, I can say the experiment was a complete success. It is WAY different from LSD. Did not even notice the come up, way more relaxing mentally as well, I prefer this to LSD, it feels like the 1st time I've tripped. Visuals are profoundly powerful. It feels extremely natural, I see why the Priest now added mint to there sacred entheogenic brew at Eleusis for 2,000 years straight, it has a very low "freak out factor", so I can see why hundreds of people could take this at once. 300ug is definetly a great dose, no less than this. 


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#9 tregar

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Posted 01 August 2020 - 02:13 AM

This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.

 

You have got to try this! It's different from ALD-52 cause it has an extra hydrogen molecule.


Edited by tregar, 01 August 2020 - 02:27 AM.

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#10 rockyfungus

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Posted 01 August 2020 - 08:36 AM

Are you claiming that even morning glory/HWBR can be soaked in sherry and mint and theoretically change the experience?

Would we want to clean an LSA solution up to remove the other chemicals that cause vasoconstriction and other negative side-effects.



#11 tregar

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Posted 01 August 2020 - 09:00 AM

Yes rockyfungus, you hit the nail on the head, see trip reports here with sherry wine and peppermint extract added to morning glory extract, simple acidified cold water extract, no chemicals, improves the experience, see reports from myself, 69ron & Kash:

 

https://mycotopia.ne...ancient-greece/



#12 rockyfungus

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Posted 01 August 2020 - 05:06 PM

Sick! Was going to plant some HBWR seeds, but will be impossible to keep a live in my arid climate.

So I guess I'll have to try this brew. Do you think 8 HBWR seeds would be enough?



#13 tregar

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Posted 02 August 2020 - 09:14 AM

Keep in mind rockyfungus that HBWR contains no LSH or penniclavine like with morning glory, HBWR only has ergometrine (17%) and rest LSA/ISO-LSA and a few minor clavines. See note (14) of linked to morning glory paper. 
 
emkee_reinvented (bluelight) said:
ALD-52 and Al-LAD both were subjectively better then 1p/1cp-LSD as well as LSD. But my memory about that last one are hazy.
 
tregar said:
This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.
 
Anonymous Dissident (bluelight) said:
More than anything else in this thread, this comment really got my attention. I absolutely adore mescaline and Tricho cacti, so this couldn't sound more appealing. I will definitely be giving this a try at some point!
 
Same here Anonymous Dissident, cactus is my absolute favorite, that's why I was surprised the 1-acetaldeyde LSD took me to a state similar to that familiar place, I absolutely ADORE the over the top beauty enhancement & euphoria with cactus, and this new alkaloid took me to that same artistic way of seeing the beauty in the world.
 
But just like cactus, the 1-acetaldehyde LSD requires higher dosages, I would compare 300ugs of this to a similar state as 300mg mescaline, I believe based on my experience, that 400ugs of this will be the "sweet spot" similar to a state of 400mgs of mescaline. And just like cactus, this is more expensive to experiment with, this requires 4 hits of acid. I don't mind the extra expense, and acid is readily available if you know where to look.
 
I also believe this would amplify small amounts of cactus quite well, say 300g to 400g of certain cacti fresh, of which I am also well familiar with, as I grow my own in backyard under shadecloth. In the past I've combined acid with small amounts of cactus more times that I can count, to amplify the beauty of the rare cactus. The open & closed eye visions were unbelievable and went on for hours, and the beauty astounding. I believe based on my experience that 1-acetaldehyde LSD will amplify the beauty of small amounts of the rare cactus to an extreme, looking forward to this in the future in dreams.
 
I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" (but not totally) and towards the adrenal A2A, A2B, and A2C spectrum instead (see chart on page 1 of this thread for explanation), which is the dominance or habitat of mescaline & dmt from hawaiian psychotria when combined with Caapi (again, see receptorome chart).
 
I also agree with poster in note (17) on page 1 above that 100ug to 200ug of this newly created alkaloid from LSD will be not be very eventful, just like 100mg to 200mg of mescaline is not that eventful, but 300ug is where this shines, just as 300mg of mescaline is a great dosage. I will report back in 2 weeks after dreaming 400ug of this new alkaloid.
 
This new alkaloid does not feel "man-made" like the semi-synthetic LSD at all, but rather very natural, primitive & infinitely beauty enhancing & euphoric just like cactus. Last night I watched a movie on TV in 4k with lots of beautiful women & scenery, and was astounded at the divine & infinite beauty amidst all the beautiful visuals with open or closed eyes, it cannot be put into words. I also listened to music for an hour and was in heaven.
 
I did notice the come up, but it was so smooth and relaxing, just like cactus. Again, this experimentation is for people who have acid to spare. If you don't have much acid to spare, recommend you stick with acid.
 
Pandemoon said:
I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and 350ug.
 
While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.
 
With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.
 
While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.
 
With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.
 
100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.
 
With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.
 
I think the higher the dose the clearer the differences.
 
Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.
Yes, as I mentioned above 1-acetaldehyde LSD has an extra hydrogen on the NH group adduct at bottom indole of the ergoline as compared to ALD-52.

Edited by tregar, 02 August 2020 - 10:07 AM.


#14 tregar

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Posted 02 August 2020 - 04:06 PM

ALD-52 and 1-acetaldehyde LSD are REAL drugs, see here, not some kind of "pro-drug": Perform the experiment I did using 300 to 400ug of acid, it will rock your world in a completely different way than LSD.
 
Yes, you guys are right about 1p-LSD, it will not fit the "very specific receptor dock" as ALD-52 or 1-aceteldehyde LSD does, even LSD scientist Dr. Nichols said it is too long.
 
1-acetaldehyde LSD is more stimulating, more like mescaline when it comes to the sky high perception of infinite beauty & euphoria, profound visuals, and relaxing mentally, no thoughts that wander uncontrollably like with LSD.
 
I was immersed in fine multi colored rainbow reflections that surrounded everything I looked at just like Pandemoon in report saw. It was indeed "like painting the air with rainbows". The beauty was breathtaking. This was different from the "colored specs in the air" I see that flow in front of everything like with acid.
 
I believe if you combine just 300ug of this with 300 to 400g of fresh cacti (no core) it will make it feel like 600 to 700g of fresh cactus, that's how close I believe the A2A, A2B & A2C receptor binding is between 1-aceteldehyde LSD and mescaline. LSD only binds to A2A in comparison, see chart on page 1 of this thread.
 
The table from Sandoz (lab where Albert Hofmann discovered LSD) suggested that ALD-52 might actually have advantages over LSD, reducing any side effects but achieving a stronger trip. Measurements of brain waves while people were taking the two drugs showed that while LSD produced brain waves associated with intense concentration and anxiety, ALD produced brain waves showing a more relaxed mental state. Sample ALD-52 trip reports given in (note 16) and (note 17).
 
In The Hallucinogens by Hoffer and Osmond (1967), ALD-52 is listed as having a lower [approximately 1/5] intravenous toxicity (in rabbits), a lower [approximately 1/8] pyretogenic effect, an equal psychological effect in humans, and double the "antiserotonin" effect as compared with LSD.
 
Also verified by reading a page on ALD-52 from the book "Ergot alkaloids & related compounds" by Berde that indeed ALD-52 has 2.1 times the "anti-serotonin" properties of LSD, and higher stimulation follows higher anti-serotonin, which may help to explain why our newly formed mystery molecule 1-acetaldehyde LSD is even more stimulating than LSD in the beginning.
 
The Aztecs and Mayans were known to add the extract from morning glory seeds (same exact alkaloid profile as the Greek claviceps paspali which grows on the grass paspalum distichum adjacent to Eleusis in the famous Rharian plain, both contain sky high amounts of LSH & penniclavine when fresh) to a drink containing alcohol (note 2).
 
We know that sherry wine contains average 10mg acetaldehyde per 30ml or shot glass. The Aztecs and Mayans apparently knew about the acetaldehyde adducting properties of wine and alcohol, which as shown in the 1992 adducts study (note 6) will cause acetaldehyde to adduct onto the bottom NH group on the indole of LSH and penniclavine forming something more akin to looking like ALD-52, (at least bottom indole wise).
 
Note (2) Page 515 "Encyclopedia of Psychoactive Plants" Christian Ratsch: "The fresh or dried morning glory seeds normally are added to alcoholic drinks (sugarcane liquor; c. alcohol), tepache (maize beer, chicha), and balche' (Schultes 1941, 37).
 
Note (6) 1992 adducts study: hxxps://www.ncbi.nlm.nih.gov/pmc/articles/PMC49935/ Page 8441 "Reaction of Indole with Acetaldehyde: A 0.2% solution of indole in equal amounts of water, ethanol, and acetaldehyde formed a product with 60% yield after 1 hour of reaction at ambient temperature. Omitting the ethanol (50% acetaldehyde in water mixture) had no effect. Decreasing the concentration of acetaldehyde to 0.1% increased the reaction rate and percent yield of product." See pic of the researchers's indole + acetaldehyde adduct product formed at bottom of this post ---> ie before (page 8439) and after (page 8441).
 
The researchers achieved a new product with or without the use of ethanol, it made no difference, you only need ph=4 acidified water and around a 0.1% acetaldehyde solution." Sherry wine not only contains avg 10mg acetaldehyde per shot glass, but is already at ph=4.
 
I will return in 2 weeks with a 400ug 1-acetaldehyde LSD trip experience. It is WAY different from LSD, see reports above.

Edited by tregar, 02 August 2020 - 05:19 PM.

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#15 tregar

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Posted 02 August 2020 - 09:48 PM

This conversion even works on seed extracts:
 
69ron (on mint/peppermint added to seed extract):
Fact: This conversion, when it works, produces an effect that is very different from LSA. Far more like LSD, and stimulating instead of sedating. When it works, the difference is HUGE, not a tiny difference, the experience is TOTALLY DIFFERENT. I know the effects of LSA and LSD very well. He has used them many times. He guarantees that when the reaction works, there is NO NOTICEABLE LSA left at all in the experience. It becomes almost identical to an LSD experience at low doses. Totally different from LSA.
 
Kash: (on mint/peppermint added to seed extract):
Just took a 40 seed portion of LSA extract that was mixed for 15 minutes with peppermint oil yesterday and tripped his face off with a friend. Was very clean feeling and relaxed. Rainbows and vibrant fractal energy danced all over the skies and throughout his surroundings and music sounded great. The head-space was very acid like but different. Was a bit intense but he was able to keep it together lol. Whole trip was about 8 hrs long.
 
I have tried a 20 seed extract without peppermint oil and it seemed uncomfortable and sedating with no visuals, while every time he has added peppermint oil he has gotten visuals.
 
Myself (500ml cold spring water acidified to Ph=4 with DL tartaric acid extract on 400 black hard fresh morning glory seeds right off vine, grown in 3/4 miracle grow + 1/4 cow manure compost) procedure given in (note 12) added 1 shot sherry and 5 drops peppermint extract to cold water seed extract as well:
Saw geometric patterns on the surface of everything, with closed eyes, colored vectors spun 360 degrees while traveling from left to right across visual plane. Sounds were not only amplified & music heavenly but audio hallucinations were produced, heavy euphoria component & very strong appreciation for beauty. Remember watching Scarlett Johansson interview on a small television and melting into the seat from her beauty amidst all the breath taking geometrics. Tripped hard as hell in dreams.
 
The priest at Eleusis added fresh mint (note 22) to their secret entheogenic brew believed to be composed of in theory ground up claviceps paspali infected paspalum distichum grass which grows adjacent to Eleusis in the famous Rharian plain.
 
Fresh claviceps paspali ergot contains the exact same alkaloid profile as the Aztec morning glory when fresh: sky high levels of LSH (lyseric acid hydroxyethylamide) and penniclavine. Animals became stimulated like with LSD when injected with penniclavine in 1958 [note 8]. Same with LSH, animals became stimulated like with LSD when injected with LSH in 1961 (note 9). As everyone knows, 2 drugs combined is more potent than just one.
 
Note [8] Ref (1) T. Yui and Y. Takeo, Japan J. Pharmacol. 7, 157 [1958].
 
Note (9) A. Glasser, Nature 189, 313 (1961)
 
Note (22) The sources were clear that the kykeon's other ingredient, mint (menthe pulegium) was fresh mint the Preist added to the brew. Mint appears to have played a symbolic role in Eleusinian myth; being Hades' concubine, Mint was "dismembered by the jealous wife Persephone." See Wasson, "The Road to Eleusis", 111.
 
Pandemoon said:
I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and 350ug.
 
While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.
 
With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.
 
While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.
 
With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.
 
100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.
 
With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.
 
I think the higher the dose the clearer the differences.
 
Also, the conversion above doesn't produce ALD52, it produces ALD52 wih an additional hydrogen molecule (if I understood correctly). That's again some different molecule that might show unique effects.

 

Yes, as I mentioned above 1-acetaldehyde LSD has an extra hydrogen on the NH group adduct at bottom indole of the ergoline as compared to ALD-52.

 
tregar said:
2 hours into it, I can say the experiment was a complete success. It is WAY different from LSD. Did not even notice the come up, way more relaxing mentally as well, I prefer this to LSD, it feels like the 1st time I've tripped. Visuals are profoundly powerful. It feels extremely natural, I see why the Priest now added mint to their sacred entheogenic brew at Eleusis for 2,000 years straight, it has a very low "freak out factor", so I can see why hundreds of people could take this at once. 300ug is definitely a great dose, no less than this.
 
This is the ONLY way I will be taking LSD from now on, deeply impressed, it has more of a cactus/mescaline feel to it, sky high appreciation for beauty, profound visuals, mentally super relaxed. I feel 300ug is only the beginning, going to take this to 400ug next time.
 
1-acetaldehyde LSD is more stimulating, more like mescaline when it comes to the sky high perception of infinite beauty & euphoria, profound visuals, and relaxing mentally, no thoughts that wander uncontrollably like with LSD.
 
I was immersed in fine multi colored rainbow reflections that surrounded everything I looked at just like Pandemoon in report saw. It was indeed "like painting the air with rainbows". The beauty was breathtaking. This was different from the "colored specs in the air" I see that flow in front of everything like with acid.
 
I believe if you combine just 300ug of this with 300 to 400g of fresh cacti (no core) it will make it feel like 500 to 600g of fresh cactus, that's how close I believe the A2A, A2B & A2C receptor binding is between 1-aceteldehyde LSD and mescaline. LSD only binds to A2A in comparison, see chart on page 1 of this thread.

Edited by tregar, 02 August 2020 - 10:17 PM.


#16 tregar

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Posted 03 August 2020 - 07:38 AM

I believe that 1-acetaldehyde LSD is shifting the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see chart on page 1 of this thread), which is the "high radioligand binding" dominance or habitat of mescaline & DMT.

 

It has a distinct feel and visual quality to it that is similar to the natural entheogens cactus & psychotria with Caapi. The enhancement of beauty is "over the top" similar to mescaline, thus I feel it would combine quite well with small amounts of fresh cactus tea.

-----------------------------------------

In conclusion, till I return 2 weeks from now with a 400ug 1-acetaldehyde LSD report:

Just a few Reddit comments below, it is obvious ALD-52 is not a pro-drug to LSD. Albert Hofmann was the one who synthesized this drug for Sandoz labs.

Also, 1-acetaldehyde LSD that was created in this thread in one-step, has an extra hydrogen on the NH group adduct at bottom indole of the ergoline as compared to ALD-52, so it will also have unique effects from that of ALD-52, of which I have posted my experience.
 ----------------------------------------
ALD-52 is probably most similar to LSD relative to the other analogues (of which I have only tried ALD-52). The headspace is markedly psychedelic, it lasts 12 hours and the visuals are prominent enough. They seemed to take on a more flowing characteristic than LSD, to where I'd see objects form within the patterns.

 I find it has a more mellow vibe than LSD, I'm more content to sit back and relax whereas 1p is supposedly closer to the electricity of LSD.

 For what it's worth, I found the come down of ALD-52 to be better than LSD... it just felt more refreshing, like a warm hug and it tapers off gently whereas LSD is more of a sudden drop off into sobriety, but the actual peak of LSD feels more... alive to me. like my consciousness is oscillating at a super high vibration.
 -----------------------
 It's not quite as euphoric as 25 or 1p, but I find it's also less prone to creating anxiety. Becuase of this, I feel like I can take much higher doses and go much deeper. I took 5 tabs and experienced absolutely no anxiety at all. I don't think I would have been able to to do the same with 25 or 1p.
 -------------------------
 Hmmm. I seem to get much more euphoria from ALD over 1p. But yes, the anxiety levels are consistently low with this chemical. ALD is an absolute gem.
 -------------------------
 Agree. I feel like it's a subtle power, not as forceful as 1p. But there's genuine depth to it.
 -------------------------
 I'll be the first to admit it may be placebo, but I also favor ALD-52 for this reason.
 -------------------------
 I dosed ALD52 like 100+ times throughout the last 4 or 5 years, in doses between 25ug and 350ug.

 While ALD52 is very similar to LSD25, I think I can still see a slight difference. To me the visuals are different, especially the tracers. I can clearly see a difference there.

 With 200ug+ of ALD52, when I move my hand it shows some very colorfull spirals and fractals in the tracer /smearing.

 While with LSD25 it is just a mirroring effect that shows several of my hands. Not nearly as colorfull, just a non colored shadow (or several) of the real hand.

 With ALD52 it's much more colorfull and intense, like painting the air with rainbow colors.

 100ug or even 150ug don't really show a difference at all to LSD25, but with 300ug and above (my highest dose was 350ug) the differences are even more intense.

 With 350ug I can hardly see reality anymore due to all those colorfull reflections of anything I look at.

 I think the higher the dose the clearer the differences.
 ------------------------------------------
 hxxps://www.reddit.com/r/LSD/comments/4ynu/highly_underestimated_ald52/

 "Yes, I realize it's not technically LSD but really, it might as well be. I took 300ug thinking it would be mild if anything. Granted it wasn't as intense mentally as LSD can sometimes be, but conceptually and aesthetically it is beautiful beyond anything I ever anticipated. I feel perfect. At one. Better than I've felt in so long. I thought I could never trip again on anything but this is honestly paradigm changing for me. ALD-52 should be considered just as powerful as LSD-25 although it's a lot more relaxed and somewhat forgiving. As it is probably apparent I'm still very deep into this experience and I hope this to be an open discussion to anyone who would like to be involved.

 My god, I just went through multiple ego death experiences beyond anything I've ever experienced from LSD before. There are no words. I mean there are plenty of "words" but none of them mean a single thing compared to any of THAT. Dear GOD. I never expected anything like this, but I sure as hell needed it. Even if I'm the only one here to express it to, as that's realistically the truth of nature anyhow. However, anyone who felt compelled to actually read through all this insanity, I just want you to know you're beautiful and you are everything. All things are right and they always will be.

 Anyway, as far as the ALD-52, I took 300ug as I said. It was amazing and stronger than I expected, however I don't think 100ug would be very eventful to be perfectly honest. If you're concerned about it being too strong 200 might be worth it but 300 was really a great amount if you ask me. Even if you haven't taken any lysergamides before ALD-52 is rather calm compared to LSD or even mushrooms for the most part. Visually though, at least for me, it was absolutely breathtaking. Colors and textures were shifting like crazy.

 Everything was alive and magical. Patterns were forming everywhere. I could lose myself so easily as the visuals seemed to drag my focus in without any effort. As a result, ego death was basically automatic and I reached that point multiple times. The first time I ever experienced ego death on LSD it left me with this beautiful feeling, like a deep inner glow that lasted for months afterwards. It eventually faded and I hadn't felt anything quite like it in years, but ALD-52 brought it back, and I feel like I've awakened from a spiritual coma.

 Another thing is LSD sometimes causes my mind to wander uncontrollably unless I take my own initiative to focus, especially during the come up which can also sometimes fill me with restless confusion. Once I peak everything usually evens out, but ALD-52 put me in a state of perfect clarity from beginning to end. The come up was so smooth and comfortable.

 I didn't notice the come down because I actually went to sleep when I felt like it was time to do so, which was an interesting surprise. Every time I've taken LSD I've had to let it run its entire course before even attempting to sleep. Often I would have to stay up for the entire day after which is obviously physically and mentally exhausting. But once I felt like the ALD-52 had made its point I went to sleep just like any other day, and woke up the next morning fully rested and mentally clear.

 Overall, it felt very natural and I never had a single moment of uncomfortability or confusion. Just pure psychedelic bliss. I mean, I've had some amazing and extremely important experiences on LSD but honestly after the other night, think I prefer ALD-52. It felt like tripping for the first time again."


Edited by tregar, 03 August 2020 - 08:23 AM.

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#17 tregar

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Posted 03 August 2020 - 12:10 PM

The proof is in the pudding, when someone else dreams this, and reports back.

The Mayans and Aztecs adding the extract from morning glory seed to beer/wine, they did not do this with any other entheogen. Sherry wine contains 10mg acetaldehyde per shot glass. The priest at Eleusis added fresh mint to their secret entheogenic brew for over 2,000 years straight, mint contains 2mg water soluble acetaldehyde per 5 drops concentrated extract.

All these ancient people were not stupid, they were quite clever, there was a reason they did what they did. Fresh morning glory contains LSH and penniclavine in sky high amounts, as does the claviceps paspali which infects the paspalum distichum grass which grows next to Eleusis in the famous Rharian plain, Both contain the exact same alkaloids. If you do this same experiment I did with LSH, it also transforms the molecule.

Here's an example: If you soak coca leaf tea bags in wine, and the wine drunk, the cocaine is converted into coca-ethylene in the liver...cocaethyelene is orally potent, it has a "higher like" rating than even cocaine when human tests were done in 1994. This was the basis behind the famous commerical "Vin Mariani wine" back in the 1860's popular with both Popes, Thomas Edison, and scores of other famous  people. I don't see any cleavage taking place with this molecule but rather addition/transformation. This "in-vivo" liver transformation of the molecule was not even discovered till 1994.


Edited by tregar, 03 August 2020 - 12:29 PM.


#18 PJammer24

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Posted 03 August 2020 - 12:45 PM

I will have to give this a try... Some the LSD I have seen recently has been so clean that there is little in the way of a come up... There is one flavor that has a more intense come up, maybe I will get that and give this a try rather than the flavors that are unbelievable smooth to start with... There is a lot of high quality L around these days but as with anything else, some is better than others... last weekend we ate sunshine barrels, which were great, but I think the lightening (owsley recipe) that has been floating around is bout as clean as I have had... It is so clean that I question if this process you describe would make much of a difference on the come up.... The visuals should be impacted even if the come up is not...

 

Hopefully I can find some time to check this out considering the raw materials are on hand or easily acquired.

 

Thanks tregar!!


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#19 tregar

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Posted 03 August 2020 - 01:21 PM

Good luck! I hope you can in dreams PJammer24.

 

For anyone that does dream this, you may be shocked at how stimulating it is the whole trip, as ALD-52 or 1-acetaldehyde LSD created via this thread has "twice the anti-serotonin power of LSD", and the more anti-serotonin or serotonin blocking (see color receptorome chart on post #1) the more powerful the stimulation, was up till 4:30am in the morning, and had dreamed it at 4pm in afternoon. The girl I was with had to tell me to "stop talking" at one point, as I kept pointing out "how beautiful the scenery was", the stimulation is high, but still mentally relaxing none the less, although a great psychedelic head space, it will take you deep mentally without the anxiety or tenseness of LSD just as Shulgin writes in TIHKAL under ALD-52 section.

It is way more colorful than acid and if you wave your hand in front of you, instead of just seeing multiples of your hand like you would with acid, you will see not only mulitple tracers, but inbetween the tracers will be fractals and swirls of color, super fine colored rainbow reflections surrounded almost everything I watched, immensely beautiful. Patterns and textures do indeed shift like crazy with open eyes. It is vastly different from LSD. With closed eyes I saw the most beautiful geometrics, before falling to sleep, saw architecture and gardens like those in Versailles, France with a fast moving groundskeeper zipping about tending to the plants, unbelievable.

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Edited by tregar, 03 August 2020 - 04:54 PM.

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#20 tregar

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Posted 04 August 2020 - 02:57 AM

I am dealing with immense criticism at dmt nexus, see thread here, this is what I told them:
 
 
Theoretical at-home conversion of LSD to ALD-52 (1-acetyl LSD) in 1 step - LSD, LSA, LSH
-------------------------------------------------------------------------------------------------------------------------------------------------------
 

Doubledog said:

My friends had some ALD52 blotters few years ago and described it as slightly more visual, and not so stimulating, and as upgraded version of LSD, but with just small difference.

I always explained it in the way that this difference is similar to difference of morphine/acetylmorphine and it is based on different metabolism of molecule.

Btw.
Title of this thread is about acetyl-LSD, but content is mainly about acetaldehyde-LSD. It's confusing.

 

Thanks for the report Doubledog from your friends, much appreciated. Take this 1-aceteldeyde LSD to the 300ug to 400ug level, it is like mescaline, which shines at the 300mg to 400mg level. Don't worry, there is none of the tenseness or anxiety of LSD, so it is easy to take it higher...but it has plenty of depth mentally. It is extremely visual at the 300ug level in a completely different way from LSD, more like mescaline or DMT in the visuals. This is for people who have plenty of acid to spare, if you do not have much acid to spare, then I recommend sticking with acid. This is just like cactus, it is more expensive to trip with, but well worth it imho, will not dream acid any other way from now on. This 1-acetaldehyde LSD imho would combine quite well with 300g to 400g of fresh cactus tea, making it feel more like 600g fresh cactus (no core).

With 300ug conversion: For anyone that does dream this, you may be shocked at how stimulating it is the whole trip, as ALD-52 or 1-acetaldehyde LSD created via this thread has "twice the anti-serotonin power of LSD", and the more anti-serotonin or serotonin blocking (see color receptorome chart on post #1) the more powerful the stimulation, was up till 4:30am in the morning, and had dreamed it at 4pm in afternoon. The girl I was with had to tell me to "stop talking" at one point, as I kept pointing out "how beautiful the scenery was", the stimulation is high, but still mentally relaxing none the less, although a great psychedelic head space, it will take you deep mentally without the anxiety or tenseness of LSD just as Shulgin writes in TIHKAL under ALD-52 section.

It is way more colorful than acid and if you wave your hand in front of you, instead of just seeing multiples of your hand like you would with acid, you will see not only multiple tracers, but inbetween the tracers will be fractals and swirls of color, super fine colored rainbow reflections surrounded almost everything I watched, immensely beautiful. Patterns and textures do indeed shift like crazy with open eyes. It is vastly different from LSD. With closed eyes I saw the most beautiful geometrics, before falling to sleep, saw architecture and gardens like those in Versailles, France with a fast moving groundskeeper zipping about tending to the plants, unbelievable.

Why so different from LSD? I think this has to do with the possibility that 1-acetaldehyde LSD shifts the receptorome or radioligand binding of receptors "away from 5-ht2a" and towards the adrenal A2A, A2B, and A2C spectrum instead (see color chart on page 1 of this thread) which is the high binding dominance or habitat of mescaline & dmt, and psilocin to a lower extent.

benzyme said:

I just don't see it...

as with LAH, that acetyl group looks like it would be cleaved with moderate [H+], the carbonyl is obviously nucleophilic. nevermind enzymatic deacetylation; it likely wouldn't even make it to the liver.

This is Happening in the Liver via an enzymatic reaction, there is no cleavage, there is transformation taking place in the liver similar to what is happening in Note (1).

The proof is in the pudding, when someone else dreams this, and reports back. smile.png

The Mayans and Aztecs added the extract from morning glory seed to beer/wine, they did not do this with any other entheogen. Sherry wine contains 10mg acetaldehyde per shot glass. The priest at Eleusis added fresh mint to their secret entheogenic brew for over 2,000 years straight, mint contains 2mg water soluble acetaldehyde per 5 drops concentrated extract.

All these ancient people were not stupid, they were quite clever, there was a reason they did what they did. Fresh morning glory contains LSH and penniclavine in sky high amounts, as does the claviceps paspali which infects the paspalum distichum grass which grows next to Eleusis in the famous Rharian plain, Both contain the exact same alkaloids. If you do this same experiment I did with LSH, it also transforms the molecule.

Note (1) Here's an example: If you soak coca leaf tea bags in wine, and the wine drunk, the cocaine is converted into coca-ethylene in the liver...cocaethyelene is orally potent, it has a "higher like" rating than even cocaine when human tests were done in 1994. This was the basis behind the famous commerical "Vin Mariani wine" back in the 1860's popular with both Popes, Thomas Edison, and scores of other famous people. I don't see any cleavage taking place with this molecule but rather addition/transformation. This "in-vivo" liver transformation of the molecule was not even discovered till 1994.

How can you all call me wrong, when none of you have even tried this? I will report back in 2 weeks with a 400ug experience. This is not a rat taking LSD mixed with a shot of sherry and 5 drops peppermint in the lab, this is a human experiment, let your liver do the work, you will see the light.

Still do this the way the study outlined, by letting all sit in fridge for 3 hours with swirling once per hour like I did. The Sherry is already at ph=4 so no acidic solution necessary.

 

The study hints at the possibility of in-vivo adduction of acetaldehyde to indole at the NH group nitrogen as well. I performed the study externally, just as the researchers did. The same study I discovered over 22 years ago, it is from 1992.
-------------------
Read the 7 paragraph trip report in Note (17) of post #1, and still tell me this sounds like LSD. One person said "this is sacrilege to convert LSD". No it's not, Albert Hofmann DISCOVERED ALD-52 as well.

 

I reposted here (my 1st home) cause I don't like the fact that Nexus only lets certain people in, I want to hear comments from all people, it is my belief that ALL should be allowed to participate, just like ALL people were allowed to participate in the sacred entheogenic ceremonies held at Eleusis in ancient Greece for 2,000 years. As a matter of fact, I will no longer being posting at Nexus, I've had enough of the criticism of myself and others...and yet they have not even dreamed this.


Edited by tregar, 04 August 2020 - 09:41 AM.

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