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New paper: HPBCD complexed DMT made 100% bioavailable sublingually under tongue


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#161 tregar

tregar

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Posted 09 October 2021 - 10:11 AM

Post #40: https://www.dmt-nexu...sts&t=97557&p=2
300mg THH + 250ug LSD report (2oz fresh sherry wine morning glory extract can substitute as well) :wub:

The combo of 300mg THH + LSD also makes the beauty & aesthetic enhancement way stronger than LSD alone, and the music sounds much better than LSD alone, it feels very much like when you combine mescaline with LSD, as THH is like the beta-carboline version of mescaline. Very beautiful combination. :wub: :wub: :wub:

10.9.2021 update: This 300mg THH + 250ug LSD combo is my absolute favorite, have since used it every 2 weeks several times now...prefer it over everything else. No re-doses necessary. Very powerful: Lasts all evening, infinitely beautiful. I've consistently reached +5 Shulgin level strength every time, very life changing experience every time. Super deep head space, Divine to the extreme, heavenly mescaline-like spiritual euphoria for hours on end, no words to describe.



#162 tregar

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Posted 21 October 2021 - 03:22 PM

On safety, see page 15 here: https://www.dmt-nexu...ts&t=96861&p=15
 
From "Discussions" page on very end of attached study, see pages 55-56:
In humans, intravenous administration of up to 3 grams HPBCD in healthy volunteers was well-tolerated and doses of 16 grams HPBCD per day given with itraconazole did not result in hearing abnormalities (4). The authors could not find examples of doses of 1000 mg/kg and higher being used in human patients although these are being proposed to treat patients with NPC disease. The authors are aware of no previous study examining the effect of HPβCD on auditory function and yet we were able to determine an effect on hearing using a small number of normal cats and cats with NPC disease. 
 
Our data show that 1000 mg/kg had no effect on the BAER response when given weekly for 14 doses between the ages of three and 16 weeks of age. Doses of 4000 mg/kg body weight resulted in an increase in hearing threshold only after repeated dosing and doses of 8000 mg/kg body weight resulted in significant increases in hearing threshold in both normal cats and cats with NPC disease following the administration of a single dose.

Edited by tregar, 21 October 2021 - 03:31 PM.





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