Yes Flashingrooster, good to see you again!, Just like Coopdog describes....this is all explained here on post #284 with trip reports from others (see Namaste's trip report):
HPBCD DMT part 1 - Pharmahuasca - Welcome to the DMT-Nexus
A chemist named Vector actually confirmed this addition to the bottom indole nitrogen ring actually occurs using TLC plates taken from morning glory seed alkaloids, years after I posted this. If it happens with those alkaloids, it surely happens with LSD at the same bottom indole nitrogen. ALD-52 was also discovered by Dr. Albert Hoffman. When Sandoz labs do brain scans comparing lsd to ald-52 they found ald-52 was stronger trip and more visual, lsd caused intense concentration, but ald-52 was more relaxed like mescaline compared to LSD.
Besides the wine used to convert LSD to 1-acetaldehyde LSD (very similar to ALD-52, or 1-acetyl LSD), check out the trip report in post #288 from JKW. Others are learning now of the combination of Tetrahydroharmine + LSD, mushrooms, etc. THH is not an maoi or rima but a full blow psychedelic serotonin reuptake inhibitor like mescaline, shrooms, lsd, ibogaine, phenomenal combo, been combining THH with 1-acetaldehyde LSD every 2 weeks for 8 months now, feels so much like mescaline + ald-52 combo, completely blown away, super-euphoric, neon colorful visual, zero anxiety, way more visual....music is insane sounding.
See this thread, part 4:
Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note (post #4)
Part 4: Tetrahydroharmine receptorome similarities to mescaline; potentiates cactus & safety note
A little off topic, but I think tetrahydroharmine is a pretty special compound. I've used 250mg of it to potentiate cactus to very strong levels, it makes a 12" medium san pedro cactus tea which may contain around 250mg mescaline feel like an X-large 12" thick san pedro cactus containing around 400mg mescaline. It makes a 12" thick bridgesii cactus feel closer to a tea made with a 12" bridgesii cactus along with an extra 6" piece.
In the data I've seen for THH, it strongly blocks serotonin just like cactus, but also agonizes the adrenal A2A thru A2C receptors (the receptors associated with aesthetics & beauty), just like mescaline has been shown to do receptorome wise, explaining perhaps why they "overlap" so well. THH being able to make mescaline in cactus feel much stronger than it really is. Anyone who has ever taken cactus or high dose THH knows the appreciation for beauty experienced is "over the top".
But you have to stagger the THH from the cactus by taking the tetrahydroharmine around an hour after the cactus is taken, that way any minor maoi's or rima's in the cactus won't interact with the SRI which is THH, which can result in a faster heartbeat for a few hours which has happened to me before...so long as you take it later, it potentiates the cactus quite incredibly...it feels like I've taken 400mg of mescaline containing cactus tea when it's really only 250mg mescaline containing cactus, and they both lasts around 6 hours with super strong activity, so they wind down at around the same time. I have around 7 months experience combining the two, giving myself around 2 weeks apart from journeys.
It works so well, I won't take cactus any other way from now on. I get much more mileage from cactus this way. Visuals and visions are insane, music is so good sounding, you would think you were an alien experiencing sound and music for the very first time, every instrument stands out on it's own, like hearing a track for the very first time.
Always take the cactus tea first, then 1 hour later take the tetrahydroharmine dose, 250mg THH makes 300mg mescaline feel like 500mg mescaline, it's incredible. THH is an SRI, so always take 1st, THEN 1 hour later take the catus tea, that way any trace maoi's in san pedro, bridgesii, torch do not interact and increase blood pressure, if you stagger by one hour, pure bliss all evening, thh half life is 10.5 hour with peak at 5.25 hour, goes great with catus, lsd, or mushrooms. Best combo ever.
Part 13: THH + mushrooms report from JKW:
Just wanted to let you know that I finally tried 3 grams of cubensis with 180 mg of THH, and all I can say is WOW! Intense and beautiful like I've never had before, with a definite DMT edge to it.
I've always been a hard-head, needing 4.5+ grams to get anywhere interesting. I've done up to 9 grams, and never got near this intensity.
Just wanted to thank you for the tip. This is the way for me to go form now on.
I look forward to combining THH with DMT.
All the best, and take care.
Edited by tregar, 31 December 2021 - 09:36 AM.