In conclusion for now:
A little bit more on LSH or Lysergic Acid Hydroxyethylamide, one of the main actives of the seeds normally, as this relates to how the new aldehyde discovery works...the fresh seeds contain around 1/4 LSH and 3/4 LSA:
Vecktor (advanced chemist like myself, from 1998):
tregar, you have probably rediscovered something that has long been a curiosity, for example on the now defunct blacklight site there was TLC posted of morning glory seed extract treated with methanol, acetaldehyde-methanol or with acetaldehyde-methanol-water, the extract treated with acetaldehyde-methanol showed a clear difference in the alkaloid profile, with a shift to several new non polar spots which couldn't be identified. Very likely the LSA converted to LSH (LSA + acetaldehyde adduct = LSH). IIRC Erhlichs was used to develop the plates so these were indole compounds.
LSD----------------------------------------CH2CH3-----CH2CH3.....chemical formula (C20 H25 N3 0)
LAE-32-----------------------------------------------H------CH2CH3.....chemical formula (C18 H21 N3 0)
d-lysergic acid hydroxyethylamide--------------H------CHOHCH3....chemical formula (C18 H21 N3 02)
* LSH was found to form in the famous 1960's paper by Arcamone when LSA or Lysergic acid amide from claviceps paspali (this ergot grows and infects paspalum grass current day on the famous rarian plane adjacent to Eleusis in ancient Greece where the psychedelic kykeon secret formula was prepared by the priest and drunk by hundreds of initiates at one time every September for 2,000 years straight) was dunked into fermented liquor which contains the aldehyde acetaldehyde. This is recounted on page 1 and 2 in the attached 2022 LSA aldehydes paper attached on post #1.
Don't get claviceps paspali, which has the exact same alkaloid profile as the Mesoamerican morning glory seeds with claviceps purpurea which has black kernels, infects barley and is poisonous, and causes gangrene and limbs to fall off. Many people even mow over claviceps paspali ergot with their mower which infects paspalum grass in the states, and don't even realize it.
1) In the middle of the book "LSD, my problem child" by Dr. Hoffman, Dr. Hoffman presents a color illustration of LSH, and labels it as one of the main psychedelic alkaloids of the seeds. He once again presents a large scale molecular model of LSH towards the end of the book "Plants of the gods" and labels it as one of the main actives of the seeds. This model even takes up 1/2 page of the book. He shows it compared or side by side with a molecular model of LSD.
2) LSH or d-lysergic acid hydroxyethylamide is very similar to LAE-32 in TIHKAL except it has one extra oxygen atom. In human experiments in TIHKAL, LAE-32 at 1.6mg resulted in LSD like effects and a stimulation unlike the sedation of LSA.
3) Dr Glasser in 1960's in a paper published in Nature showed that when LSH was injected into mice, the mice responded as if they had been given a substance similar to LSD, they became very active and even pressed on each other's noses. Glasser A (January 1961). "Some pharmacological actions of D-lysergic acid methyl carbinolamide". Nature. 189 (4761): 313–4:
https://www.nature.c...ticles/189313a0
4) LSH was given to a person in 2020 and a receptorome or radioligand chart was mapped showing what receptors in the brain it hits, with many similarities to the receptors LSD hits:
http://www.t3db.ca/toxins/T3D3687
When preparing LSH from LSA + acetaldehyde as given in instructions above using the discovered new aldehyde which I will disclose when book comes out, when using acetaldehyde you must remember that acetaldehyde evaporates off at room temp or right above 69 degrees F. So when spinning the solution in ph=4 wine high in acetaldehyde wine such as sherry (contains 10mg acetaldehyde per shot glass) for 1 hour with a dash of vinegar to catalyze the condensation reaction, the spinning must be done on an ice bath or in the fridge on a battery powered magnetic stirrer to keep the acetaldehyde from boiling off which happens at around 69 degree F.
Luckily, this newly discovered aldehyde when condensed or adducted onto LSA with effects very similar to actual LSD has a high boiling point right below the boiling point of water, and all this formation can be done at room temp.
When the ancients prepared this new aldehyde product with a handfull of the fresh herb high in this specific aldehyde mixed with the powdered claviceps paspali ergot in wine, they most likely also added a dash of vinegar or used wine which had been sitting out un-corked for a few days, as a portion of the wine will convert to vinegar if not sealed with an inert gas to prevent oxidation. This is actually good, as this is what they needed, wine with a tiny amount of vinegar.
When preparing the new potent condensation product from the discovered aldehyde + LSA which I will disclose at the end of summer, you must use a tiny splash of vinegar to catalyze the condensation reaction as explained in attachment, where the researchers formed new condensation aldehyde products with acetamide + chosen different aldehyde.
By the way, acetamide in the paper looks identical to the amide group on LSA which we are using.
Pic 1: chemical formula for entry #16....3-aminopentane = CH(C2 H5)2
diethylamine from LSD has 4 carbon groups and 11 hydrogen groups with a molecular weight of 73 g/mol.
Both the 3-aminopentane and the aldehyde of this new discovery have 5 carbon groups and 11 hydrogen groups (once the aldehyde attaches to the H already at the amide of LSA) and BOTH have exact same molecular weights of 87 g/mol similar to diethylamine molecular weight of LSD at 73g/mol.
The 3-aminopentane from Dr. Nichols and this new aldehyde discovery join at the R1 substitute of LSA with R=H still. This new aldehyde has same molecular weight as 3-aminopentane on the R1 substitute of LSA with R=H, see Dr. Nichol's paper on page 84, chart shown. This is one of only 2 entries in which the rats responded to it (3-aminopentane) as if they had been given LSD.
Dr Nichols:
The important thing to note from the table below, in the far right column, is the fact that LSD has a potency in rats in the drug discrimination behavioral assay of 48 nanomoles per kilogram of rat body weight. Only two other compounds have comparable activity: entries 6 and 16.
Curiously, entry 6 is a monoalkylamide that has the same molecular weight as LSD itself, that is, it has a total of four carbon atoms attached to the amide. Entry 16 has a five-carbon group attached to the amide.
We have no evidence as to whether either of these compounds would be active in man, but these rat data suggest that they might be.
3-aminopentane has a potency in the drug discrimination behavioral assay of 52 nanomoles per kilogram of rat body weight, this is very similar to the 48 nanomoles per kg of rat body weight observed with LSD.
Pic 2: Description of 3-aminopentane by Dr. Nichols and why it is important.
Pic 3: how acetamide + new aldehyde condensation product is formed. LSA or Lysergic acid amide in the seeds has an amide group just like acetamide.
Pic 4: LSH, LSA + other minor alkaloids profile in morning glory seeds from 2016 Polish mg study, claviceps paspali ergot infects paspalum grass, and color illustration of LSH from "LSD, my problem child". Note: HBWR contains very high levels of ergometrine which causes cramping and vasoconstriction, while mg seeds contain very low levels of ergometrine, which is why mg seeds should only be used. HBWR only has history of medicinal use while MG seeds have hundreds of years of Shamanic use.
Pic 5: Molecular model of LSD compared with LSH from morning glory seeds towards end of book "Plants of the gods" by Dr. Hoffman. Also see chapter on morning glory seeds.
p.s. magnetic stirrers are cheap and can be found at auction or *mazon for less than fifty dollars.
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Part II:
How to make the zero nausea morning glory liquid which is used for all aldehyde experiments, example: forming LSH from the LSA in the seeds:
Easy steps, I've used this process over a dozen times in a year period, it works:
Pic 1: Drink this LSH enhanced liquid extract at the same time you drop your LSD for an experience that is way beyond LSD, the LSH adds infinite dimensions to the normal LSD experience, like incredible (I mean phenomenal !) music enhancement, every sound in the music is "epic", infinite beauty enhancmenent, strong sensual feelings, strong neon like color saturation, flowing visuals, energy fields seen in constant motion all objects, heavy tracers, etc. These qualities LSH adds are very similar to what cactus tea adds in my experience when added to LSD.
This is most likely due to LSH hitting 5 more adrenal recpetors associated with beauty, aesthetics and sensuality beyond normal LSD, see radioligand chart for LSH. I used this potion every time I tripped, you can even add it to cactus tea by taking drinking the LSH potion 1 hour later (always stagger 1 hour so the amides do not clash with the trace maoi's in cactus, only take in that order) it's incredible.
How to make the zero nausea morning glory liquid which is used for all experiments, example: forming LSH from the LSA in the seeds:
Pic 2: How this works, from 2022 aldehydes paper, see 1960's study by Arcamone.
Pic 3: Sherry wine is the wine highest in acetaldehyde.
Pic 4: With only a lamp on in garage, no overhead bright light: grind 15 grams or 525 heavenly blue morning glory seeds in a coffee grinder (35 seeds per gram) using 10 second grind with occasional shaking of coffee grinder, pause 5 seconds, then grind again 10 seconds, repeat x 4 times, you will end up with a dust like consisteny, all the alkaloids are extracted from within the tough rubbery embryo of the seed. 525 seeds x .01mg LSA per seed = 5mg LSA
Pic 5: Place ground seed dust into a 1/2 pint tall jar (*almart case of 12, canning section), add 3.5 to 4 shots of cold just opened fresh sherry wine from the fridge, and around 30mg of DL tartaric acid which aids the extraction (from hi media store, *mazon, auction or similar). Do not use plain L-tartaric acid used in wine making, get the good stuff, which contains the D isomer. D-lyergic acid amide isomer salts are the potent form of salts.
And also ADD a tiny splash of acetic acid or VINEGAR to catalyze the condensations of the aldehyde to LSA: acetaldehyde in this case onto the amide of LSA. The vinegar acts as an important catalyst, and is needed for the formation of new product and will not form without it, see study from post above.
Re-seal your sherry wine by spraying wine preservation canister which has inert gas (contains argon, carbon dioxide, etc.) around ten dollars from *mazon into your wine before sealing with cork and placing back in fridge, this way the precious acetaldehyde in the wine will not oxidize to vinegar as normally happens over a 5 day period when corked without preserving.
Step 6: Put lid on and shake contents for 1 to 2 minutes, at this point you would add your discovered aldehyde 3 drops before shaking to form new molecule similar to LSD in every way. But this will not be disclosed until end of summer. With the new aldehyde discovery I will disclose at end of summer, I spin the wine on magnetic stirrer with splash of vinegar at ambient room temp with 3 drops of the discovered aldehyde for 1 hour at very high speed to form the new molecule with effects very similar to actual LSD in every way.
Place jar into fridge for 10 minutes after the 2 minute shaking, during this time the nauseating seed debris can be seen falling to the bottom.
Pic 6: Filter entire contents of jar thru a "coffee wire filter" from *almart or *amazon or your local grocery store sitting atop a glass, the liquid above the seed debris will filter real fast in seconds, then filter the debris at the bottom from the jar, once the debris is in basket, use a spoon to press down on it to get all the liquid out, this only takes around 10 seconds.
Pic 7: Place this filtered liquid in the fridge for 3 hours or even overnight, within 3 hours, all of the nauseating to the intestines seed debris will have fallen to the bottom. This process begins within an hour after sitting in fridge, check each hour and watch as the seed debris falls by around an inch each hour.
Pic 8: After 3 hours or longer, decant the liquid from above the bottom 1/4" of seed debris, this is what you want to consume, it is psychedelic and results in zero nausea, as there is no seed debris in it. DO NOT DRINK the SEED DEBRIS at very bottom or you will become nauseated and sick, don't worry, there are no alkaloids in it.
All the alkaloids are concentrated in the fridge decanted liquid above the seed debris. This contains your LSA which has adducted to the acetaldehyde in the wine, forming new amounts of LSH, since the wine is at ph=4, the new LSH adduct product will remain stable indefinately, store in fridge if you plan to use within a few days, or you can freeze and de-thaw in fridge overnight to use next day. It dethaws fast since it is wine.
Note: never try to extract your seeds using just plain acidified water, I have tried this before, your seed debris will not separate out in the fridge, and you end up with a complete emulsion in the coffee wire filter which will not filter at all, wine is needed to effect the proper extraction, and allows the liquid to separate from the seed emulsion below, this will not happen with a plane water extration. This is how the ancient Aztec and Mayan extracted the seeds using balche, an alcohol they made themselves, see 2nd pic.
Edited by tregar, 10 February 2023 - 10:54 AM.
