The two links Condo gave above to the peganum extractions are good to go. 1 gram of the said hcl extracted material was used quite extensively by forum members sync and meteor at ayahuasca.com. Some at the forum have said that b.caapi, peganum harmala, or pure harmine hcl are better teachers than moclobemide:http://forums.ayahua...ght=moclobemide
I currently prefer to use pure crystalline harmine hcl at a dosage of 170 to 190mg, but it is about $8 a dose (about the same expense as a brewed caapi dose). In a few weeks I'll be combining it with muriatic hcl brewed and filtered Hawaiian psychotria evaporated extracts.
From 'Ayahuasca' by Ralph Metzner:
Average amounts, and ranges, of body weights, amounts of tea ingested, and total amounts of alkaloids consumed by fifteen volunteers during the pharmacokinetic phase of the Hoasca Project. These results are presented in terms of kilograms (kg) body weight, milligrams (mg) of alkaloid, and milliliter (ml) of tea ingested:
Body weight -- 74 kg
tea -- 148 ml
harmine -- 252 mg **(major component in caapi, along with THH)
harmaline -- 30 mg **(only trace amounts found in caapi -- not enough to be active)
tetrahydroharmine -- 159 mg **(this is a very mild serotonin reuptake inhibitor)
dmt -- 36 mg
body weight 58 - 90 kg
tea -- 120 to 180 ml
harmine -- 204 to 306 mg
harmaline -- 24 to 36 mg
tetrahydroharmine -- 128 to 193 mg
dmt -- 29 to 43 mg
I have taken a dose of pure harmine hcl over 200 mg by itself without anything else (but would only use about 160 to 190 mg when using with dmt in the future) and had closed eye visions of scenes related to nature and/or culture including animals, architecture, gardens, and people...but the visions though highly detailed were colored in dark greens and blues--they were not bright at all--dmt if added would no doubt add "the light". I do not recommend taking penalty doses of just the maoi to obtain visions (higher than 200 or 250 mg of pure harmine, or large doses of caapi, peganum, etc.) as this also results in sea-sickness when moving and loss of appetite--all lasting 4 to 6 hours or so. When the correct dose of maoi is taken (but there will be no visions without adding the dmt or plant-containing dmt) there will be no sea-sickness, no loss of appetite, or any significant loss of balance--just relaxed sedated feelings like being in a hot tub.
And a few tidbits of wisdom concerning the use of pure harmine hcl (composes avg of 69% alkaloid content of a caapi brew):
Sync "in a dream" used 250mg harmine hcl and appoximately 20 cc of tea. Sync quote (2001): "Taken 20 minutes after the harmine and with a small piece of chocolate cake. The results were spectacular to say the least. I believe that taking the harmine in closer proximity to the tea, and having some fat containing food directly on top of the harmine, may have been a significant factor in the power of the experience."
GodofEmptiness quote (2002): "My delusional brother's pit bull has access to pure harmine and harmaline, and found that for his weight, 120 kilos, (it's a big dog), approx 200mg of pure harmine is enough to provide the needed effect and a spectacular dream -- the dream was excellent -- This dreamer would recommend Harmine HCL if available to other dreamers."
Sync quote (2001): "The harmine seems very gentle and clean, far easier on the body and neurons than either of the natural plant sources. The anti-depressant effect with pure harmine is an order of magnitude greater than rue or the vine, and the spirit, well, to say it was present would be an understatement. There also seems to be a greater ability to experience the depths of emotions in a healthy way. I think it may be time for some to concider that the spirit of the plants is not confined to just the plants..."
Delysid quote (2001): "I have used pure harmine in a brew before. The thing is that I did not use a purified psychotria extract just a viridis tea so there was still a ton of sludgy garbage in it. I still received nausea but it was noticably less then with my usual caapi/peganum harmala seed brew, probably due to the lack of unneeded maoi's. As far as the effects go, the only difference that I noticed was the taste...the effects were the same as if I used the vine. Thus I doubt that THH nad hamaline contribute much to the brews effects."
Mckenna "The Invisible Landscape" (1994): "Graph # 7 from Smythies and Antun, "Binding of Tryptamines and Allied Compounds to Nucleic Acid," Nature, 223: p. 1062, Sep. 6. 1969. shows that there is not much difference in the reduction in fluorescence of harmaline (-42) and tetrahydroharmine (-38) in reaction with DNA or RNA, but harmine with its bulkier ring system appears to bind better to DNA (-90). Smythies's model is supported by evidence that 5HT and many of its analogs, including LSD-25, N, N-DMT, and harmine can bond to DNA, RNA, or both."
Food for thought: Jeremy Narby has an off-beat notion that intelligent interactive video messages have been recorded on DNA by some higher intelligence and that we all see the same things because we are all one at the level of DNA.