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One pill makes you better ...Ibogaine


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#21 Guest_lost_onabbey_rd_*

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Posted 13 December 2005 - 02:58 PM

everything except for cigarettes and booze
LOST

#22 anticheffy

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Posted 13 December 2005 - 07:13 PM

ya, the real killers arent even on the list

#23 phalanx

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Posted 04 January 2006 - 11:13 PM

http://www.ibogaine.org/alkaloids.html

I was reading up on iboga and thought the trip descriptions had some similarity to the vine-only trips I had, and rue-only trips. I did some research and found this. I got it from the conclusion of the discussion at the link above.

"Recent structure activity studies demonstrate that O-desmethylibogaine, which is less potent than ibogaine at NMDA receptors, appears as active as ibogaine in acutely blocking morphine and cocaine self-administration. This observation strongly suggests that other mechanisms may be operative. A similar argument can be made for harmaline, which is somewhat structurally related to ibogaine and shares some of its pharmacological actions (e.g., tremor and neurotoxic effects, reductions in cocaine and morphine self-administration), but is not an NMDA antagonist. Although inhibition of drug self-administration by harmaline may be due to unspecific effects (e.g., general malaise), these findings nonetheless raise the possibility that ibogaine's anti-addictive properties may be produced through multiple mechanisms. The involvement of sigma sites in these phenomena appears to be even more obscure because in contrast to ibogaine, harmaline has no appreciable affinity at sigma sites whereas O-desmethylibogaine lacks affinity at a sigma2 site, yet all three block cocaine and morphine self-administration. "

#24 Elf Salvation

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Posted 04 January 2006 - 11:17 PM

:cool:
Nice Phalanx

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#25 Guest_pissybee_*

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Posted 05 January 2006 - 05:00 PM

I bet the trip isn't very similar... On iboga, I was in like a waking dream state for over a day, with constant closed eye visions. Just like a dream...

#26 phalanx

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Posted 05 January 2006 - 08:14 PM

Yes the trip sounds quite different tho. You took the indra extract, 3g?

edit: 5g, read your report. I think 3g would be enough for me!

#27 Guest_pissybee_*

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Posted 06 January 2006 - 01:55 AM

I took the extract from a friend, who had it extracted for treating patients/clients.. I have heard mixed reports about indra's extract, so I am not sure of quality...

#28 Master_Shake

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Posted 05 March 2006 - 08:32 PM

well its was full a grammatical errors, but the information is intersting for sure.

not that "our" goverment wants us to use anti-addiction meds like this one. they want us to use thier non-effective ones that you have to continue taking forever. goverment loves addiction. LOVES IT! because they love money more than people, quality of life or even thier own god.

M O N E Y ! M O N E Y ! M O N E Y ! M O N E Y ! M O N E Y M O N E Y !


those trying to make this a usable helpful drug great, more power to them. but they WILL fail. as is,this chem will never become (legaly) avilable for those who need it. it will not happen. sad as it may be.


S H A K E

three cheers for uncle sam....

#29 mushit

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Posted 05 March 2006 - 10:54 PM

Yup. It's the same as they don't want people to know that THC shrinks certain types of cancer tumours. Just imagine what would happen to the billions of dollars that the cancer research society rakes in if they had a cure for it.

Hmmmmmmmm

#30 Hippie3

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Posted 08 April 2006 - 08:23 AM

well its was full a grammatical errors, but the information is intersting for sure.


it's my opinion
that few things look sillier
than someone making comments
about someone else's grammer
with a sentence full of
mis-spelled words and errors of their own.
:lol:

#31 frmars

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Posted 23 April 2006 - 04:42 PM

Hello,
Just discovered the forum. As part of a psychotherapy, I am looking for ibogaine. I currently live in France and haven't got the slightest clue of where I could get any.
Can someone on this forum direct me or advise me on that matter ?
You may also write to me directly : [email protected]

Any help appreciated. Thanks.

#32 Id13

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Posted 24 April 2006 - 12:41 AM

Hello, I recently wrote a paper for my psychology course on the use of psychedelics in treatment of drug-addiction, which was partially inspired by this thread (heard about Ibogaine from it).

Here is some of what I learned and wrote about from reading multiple studies, several involving Ibogaine (sorry if there is any repeated information):

There is concern that Ibogaine is neuro-toxic, which is why there has been less studies conducted with it and why it is illegal.

Ibogaine blocks multiple drug cravings and lessens withdrawal symptoms through its role as a NMDA receptor antagonist.

Several other substances also act as NMDA antagonists, such as dextromethorphan, ketamine, and MK-801. These have been shown to produce similar results to Ibogaine.

A novel iboga alkaloid congener, 18-MC, has been shown to have similar anti-addictive effects to Ibogaine and is not considered to be neurotoxic.

From what I read, the most promising psychedelic for anti-addiction treatment appears to be ketamine. I found this because it helps alleviate withdrawal and cravings as a NMDA antagonist, a single ketamine session has shown to have long lasting anti-depressent effects, and succesful tests have shown psychedelic psychotherapy with ketamine to help patients recover from drug addiction.

#33 mindovermycelia

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Posted 24 April 2006 - 08:04 AM

yeah, but K is like psychedelic smack - highly psychologically addictive

#34 Hippie3

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Posted 24 April 2006 - 08:07 AM

There is concern that Ibogaine is neuro-toxic, which is why there has been less studies conducted with it and why it is illegal.


perhaps
but one must give such info hard scrutiny
as we know we have been lied to
in the past.

#35 I_am_me

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Posted 24 April 2006 - 09:40 PM

yeah, but K is like psychedelic smack - highly psychologically addictive


Are you sure K has addictive properties? I've done plenty and after a night of snortin lots of K I never wanted to get up the next day and do more bumps.

#36 Mycolangelo

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Posted 25 April 2006 - 09:22 AM

The drug companies are hand in hand with the govt. They don't want drugs out there that work with one dose, where's the profit! What about our shareholders and we need to increase our top Exec's comp packages. After all they have the money to contribute to political campaigns.

#37 Id13

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Posted 25 April 2006 - 01:14 PM

I don't have too much time, but here are a few excerpts from a more recent study done to investigate neuro-toxicity:

"In previous studies in the rat, ibogaine caused degeneration
of Purkinje cells in the cerebellar vermis (10,11). Behavioral
studies in rats are suggestive of an acute disruption of
sensory-motor performance, as well as deficits in learning after
a single injection of ibogaine. Unlike the sensory-motor effects,
the memory deficits persist for several days (5). Indeed,
it has been suggested that ibogaine’s putative anti-addictive
effects arise from an interference with learning and memory
processes (5).
The radial maze has been used to assess the effects of
drugs and of brain lesions, induced either electrically or chemically,
on learning and memory (12). Most relevant to the
present investigation is the observation by Kesner et al. (5) of
“a significant disruptive effect on spatial learning 1–3 days after
the ibogaine injection, but no long-term consequence 7–9
days later.” These investigators also reported that ibogaine
caused an acute disruption of sensory-motor performance (5).
In the present study, the effects of ibogaine on acquisition of a
new task and on performance of an already learned task in the
8-arm radial maze were examined."

"In the present study, ibogaine failed to produce any detrimental
effect on either acquisition of a novel task or performance
in a previously learned task in the radial maze."

"When dealing with a putative neurotoxic agent, the main
concern regarding carryover is that it may result in an overestimation
of the toxic effects of the substance in question. If
ibogaine had a deleterious effect on maze performance, carryover
could only enhance this effect. The failure of ibogaine to
elicit such effects, together with the fact that the ibogainetreated
group committed significantly fewer errors in Phase
III, strongly suggests that ibogaine does not have a detrimental
effect on performance in the radial maze. Whether the results
presented in Fig. 3 reflect an ibogaine-induced enhancement
of learning and memory is not clear at present.
In conclusion, the present investigation failed to demonstrate
any deleterious effects by ibogaine on either acquisition
of a novel task or efficiency in the performance of a previously
learned task."

What I said earlier is that there is concern over its neurotoxicity and more careful testing is required to fully investigate this possibility; that's why they refer to ibogain as a "putative neurotoxic agent". Basically, I wouldn't take ibogaine until there is definitive evidence of its neurotoxicity.




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