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Psilocybin - summary of knowledge and new perspectives (2014)

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#1 MrGumball


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Posted 30 August 2015 - 05:18 PM

Psilocybin - summary of knowledge and new perspectives

European Neuropsychopharmacology (2014) 24, 342-356





Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to its potential therapeutic effects. However, it is also a very popular and frequently abused natural hallucinogen. This review summarizes all the past and recent knowledge on psilocybin. It briefly deals with its history, discusses the pharmacokinetics and pharmacodynamics, and compares its action in humans and animals. It attempts to describe the mechanism of psychedelic effects and objectify its action using modern imaging and psychometric methods. Finally, it describes its therapeutic and abuse potential.








In summary, psilocybin has a strong research and therapeutic potential. Due to the good knowledge of its pharmacodynamics and pharmacokinetics, beneficial safety profile and zero potential to cause addiction it is frequently used both in animal and human research. It brings a number of key findings regarding the functioning of the human brain, in particular the role of the serotonergic system in complex functions such as perception and emotions. It also serves as a useful tool for the study of the neurobiology of psychoses. Due to its considerable degree of translational validity of animal and human studies, a psilocybin model of psychosis plays a key role in the development of new treatments for psychotic disorders. Finally, the most recent human studies also suggest its potential therapeutic use in the treatment of several psychiatric and neurological disorders.

Edited by MrGumball, 30 August 2015 - 05:26 PM.

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#2 Heirloom


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Posted 30 August 2015 - 06:48 PM

interesting but I don't know for a fact that it is abused.

as a model of psychosis?

 I don't know that taking some
psilocybin is equal to being psychotic.

a mushroom trip is a lot easier to handle than psychosis is.

we don't see people on mushrooms acting out as psychotics do.

animal experiments with psilocybin seem cruel and not of much value.
most animals ( maybe talking bonobos) can't express in definite words
what's going on in their minds. looking at their neural chem interactions
is a fuzzy  view at best, might give some insight into consciousness .

there's a long way to go before they understand the mind.

therapeutic use I agree it has great potential to help humanity.

just a few random thoughts from a hairless ape with no degrees but some
psychedelic experience.

 a nice post like to here what others think.


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#3 SteampunkScientist


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Posted 08 September 2015 - 12:45 PM

No mention of the fact that physically speaking its safer than most vitamins to take.
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#4 morfin-56


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Posted 09 September 2015 - 03:53 PM

More research needs to be done on its brain cell regenerating effects I think that is awesome in its self and I could also see uses in negating mental illness.

Edited by morfin-56, 09 September 2015 - 03:55 PM.

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#5 Saphroziac


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Posted 10 September 2015 - 10:17 PM

Who cares if it is abused. We don't need to enforce that; the mushroom will do what it pleases with the unknowing suspect.

#6 riseabovethought


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Posted 11 September 2015 - 12:40 PM

More confirmation this work is impressively important.  Thanks Mr Gumball.

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