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DEA is at it again placing CBD extracts on schedule 1


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#1 CatsAndBats

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Posted 15 December 2016 - 10:37 AM

Seriously, what the fuck?! What a bunch of bullies. They've ruined countless lives already, now they're really reaching, again.

 

Original here: https://www.yahoo.co...-083035386.html

 

 

 

United States’ Drug Enforcement Administration (DEA) on Wednesday set new cannabis extract laws by amending the Schedule I Controlled Substances Act to include tighter regulations for marijuana extracts, including cannabidiol (CBD).

 

In the new drug code titled “Establishment of a New Drug Code for Marihuana Extract,” the DEA says it is “creating a separate code number for marihuana extract with the following definition: ‘Meaning an extract containing one or more cannabinoids that has been derived from any plant of the genus Cannabis, other than the separated resin (whether crude or purified) obtained from the plant.’ Extracts of marihuana will continue to be treated as Schedule I controlled substances.”

 

This means CBD and all other extracts derived from the cannabis plant (psychoactive or not) will come under Schedule 1 drugs, like heroin, LSD, marijuana, and ecstasy, and cannot cross state lines. Any person currently licensed to produce and handle marijuana extracts is required to apply for a modification of their registration by Jan. 13, 2017, the new document says.

 

“For practical purposes, all extracts that contain CBD will also contain at least small amounts of other cannabinoids. However, if it were possible to produce from the cannabis plant an extract that contained only CBD and no other cannabinoids, such an extract would fall within the new drug code,” the DEA said.

The declaration, which critics say was made silently to avoid criticism, was justified with the help of international treaties: “Under international drug control treaties administered by the United Nations, some differences exist between the regulatory controls pertaining to marihuana extract versus those for marihuana and tetrahydrocannabinols.”

 

“The DEA has previously established separate code numbers for marihuana and for tetrahydrocannabinols, but not for marihuana extract,” the document’s summary read.

 

Medicinal marijuana activists, however, are questioning the legality of the move.

“This action is beyond the DEA’s authority,” Robert Hoban, a Colorado cannabis attorney and adjunct professor of law at the University of Denver, told Leafly. “The DEA can only carry out the law, they cannot create it. Here they’re purporting to create an entirely new category called ‘marijuana extracts,’ and by doing so wrest control over all cannabinoids. They want to call all cannabinoids illegal. But they don’t have the authority to do that.”


Edited by catattack, 15 December 2016 - 10:42 AM.

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#2 CatsAndBats

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Posted 15 December 2016 - 10:40 AM

Meanwhile the FDA is questioning the move:

http://www.fda.gov/N...y/ucm453989.htm

 

Cannabidiol: Barriers to Research and Potential Medical Benefits

Statement of

Douglas C. Throckmorton, M.D.
Deputy Director for Regulatory Programs
Center for Drug Evaluation and Research
Food and Drug Administration
Department of Health and Human Services

Before the

Caucus on International Narcotics Control
United States Senate

June 24, 2015

INTRODUCTION

Chairman Grassley, Co-Chairman Feinstein, and Members of the Caucus, I am Dr. Douglas Throckmorton, Deputy Director for Regulatory Programs at the Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA or the Agency), which is part of the Department of Health and Human Services (HHS). Thank you for the opportunity to be here today to discuss the important role that FDA plays in the regulation of researching marijuana, including its constituent compounds, such as cannabidiol, for potential medical uses. This is an important part of FDA’s mission to protect and promote the public health by helping to ensure the safety, efficacy, and quality of medical products, including drugs. In addition, I will briefly discuss the regulatory oversight function of the Agency with respect to other products that may contain cannabidiol.

FDA plays a critical role in regulating the development and potential use of cannabidiol and other constituents of marijuana as prescription drugs in the United States. FDA also, on its own and in partnership with other Federal agencies, supports the efficient and scientific assessment of cannabidiol and other constituents of marijuana in drug development. These activities are critical, if safe and effective drugs are to be developed from marijuana, including from its constituent components such as cannabidiol. FDA continues to believe that the drug approval process represents the best way to help ensure that safe and effective new medicines, including any such medicines derived from cannabidiol or other constituents of marijuana, are appropriately reviewed for safety and effectiveness, consistent with FDA’s statutory requirements. It is important and appropriate to use the same scientific standards in the development and assessment of potential therapeutic uses of cannabidiol as with any unapproved drug that the Agency reviews.

FDA's Role in Reviewing Cannabidiol as a Potential Prescription Drug

The role of FDA in the regulation of cannabidiol as a potential prescription drug relates to our larger responsibility for the regulation of all drugs intended for human use. The Agency reviews drug product applications to determine whether drugs are safe and effective for their intended uses. Any product intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease is classified by FDA as a drug. This applies regardless of the product’s form, the product’s active or inactive ingredients, or the way in which the manufacturer chooses to market and label the product.

In approving a drug for marketing, FDA reviews important information about the drug, including:

  1. The indication for which the drug has been studied, including specific uses in children or the elderly, if any
  2. Which patients may benefit from its use, including information about whether the drug has been tested in children
  3. What adverse effects have been reported for individuals taking the drug
  4. How the drug should be taken (e.g., orally, intravenously)
  5. The dose of the drug recommended in the intended patient populations
  6. How the drug is made (e.g., as a pill, liquid) and what is in the drug, including both active and inactive ingredients

Getting a drug approved requires the collection and submission to FDA of clinical and non-clinical data about the proposed use of the drug for review as part of a New Drug Application (NDA) or Biologics License Application (BLA). Usually, the first step that a sponsor takes to obtain approval for a new drug is to test the drug in animals to determine drug toxicity. The sponsor uses those animal data, along with additional information about the drug’s composition and manufacturing, to develop a plan for testing the drug in humans. The sponsor submits the animal data to FDA in the form of an Investigational New Drug (IND) application that includes protocols describing proposed human studies, the qualifications of the investigators who will conduct the clinical studies, and assurances of informed consent and protection of the rights, safety, and welfare of the human participants. FDA reviews the IND to confirm that the proposed studies, generally referred to as clinical trials, do not place human participants at unreasonable risk of harm. FDA also verifies that there are adequate assurances of informed consent and human subject protection. At that point, drug testing in humans can begin.1

Typically, the initial clinical trials (Phase 1) assess how to safely administer and dose the drug when used in small numbers of healthy volunteers. If Phase 1 trials are successful, Phase 2 studies explore the effectiveness of the drug for a particular indication, over a range of doses, and determine short-term side effects. If Phase 2 studies are successful, pivotal Phase 3 studies are designed based on the information learned in the earlier studies to further study safety and assess the efficacy of the investigational drug for a particular indication in a defined patient population. Phase 3 studies also can provide additional safety data, including long-term experience effects of the drug in certain patient groups, and efficacy of different doses of the drug. These later trials sometimes enroll several hundreds to thousands of participants—depending on the indication studied—to provide essential information about the investigational drug’s safety and efficacy. Following the completion of these studies, the data might be submitted to FDA in an NDA or BLA for the Agency to review. Throughout the development process, FDA strongly encourages sponsors to work closely with the Agency to support efficient drug development.

In addition to establishing the safety and efficacy of the investigational drug, manufacturers also must demonstrate that they are able to consistently manufacture a high-quality drug product. This is an essential part of drug development and presents special challenges when the drug is derived from a botanical source, such as marijuana. Botanicals include herbal products made from leaves, roots, stems, seeds, pollen, or any other part of a plant. Botanical products pose challenges that are unique to this class of product, including lot-to-lot consistency. These unpurified products, which may be either from a single plant source or from a combination of different plant substances, can have effects through unknown or undefined mechanisms, making it difficult to determine if the product is causing the change in a patient's condition, or the change is related to some other factor. For these reasons, a focus of drug development for botanicals is identification of a source that will provide the necessary assurance of consistent quality, lot to lot. To support development of drugs derived from botanical sources, FDA has released guidance providing information on the development and approval of such drugs that addresses these issues, as well as providing more general recommendations on studying botanicals.2

Another important consideration is the need to identify a method to consistently provide a given dose of a drug. When the Institute of Medicine (IOM) reviewed the potential clinical use of marijuana, it identified the problems associated with obtaining consistent dosing using smoked products and recommended that clinical trials involving marijuana should be conducted with the goal of developing safe, alternative delivery systems:3

If there is any future for marijuana as a medicine, it lies in its isolated components, the cannabinoids and their synthetic derivatives. Isolated cannabinoids will provide more reliable effects than crude plant mixtures. Therefore, the purpose of clinical trials of smoked marijuana would not be to develop marijuana as a licensed drug but rather to serve as a first step toward the development of nonsmoked rapid-onset cannabinoid delivery systems.

Another consideration related to the regulation of cannabidiol as a potential medicine is its status as a constituent of a controlled substance, in this case marijuana. Under section 202 of the Controlled Substances Act (CSA), marijuana is currently listed as a Schedule I controlled substance.4 Schedule I includes those substances that have a high potential for abuse, have no currently accepted medical use in treatment in the United States, and lack accepted safety for use under medical supervision.5 Nevertheless, Schedule I substances, including drugs such as marijuana, can be and are the subject of clinical trials under the Federal Food, Drug and Cosmetic Act (FD&C Act), provided, among other factors, that FDA authorizes an IND application submitted by a sponsor. In addition, the CSA requires researchers to register with the Drug Enforcement Administration (DEA) before handling Schedule I controlled substances, including conducting clinical trials.6

Through the drug development processes described above, FDA has approved two drugs for human use which contain synthetic cannabinoids: Marinol (Schedule III) and Cesamet (Schedule II). FDA approved Marinol capsules in 1985 for the treatment of nausea and vomiting associated with cancer chemotherapy in patients who had failed to respond adequately to existing antiemetic treatments. Marinol capsules include the active ingredient dronabinol, a synthetic delta-9-tetrahydrocannabinol, or THC, which is a psychoactive component of marijuana. Marinol capsules were also approved in 1992 for the treatment of anorexia associated with weight loss in patients with AIDS. FDA approved Cesamet capsules for the treatment of nausea and vomiting associated with chemotherapy in 1985. Cesamet capsules contain the synthetic cannabinoid nabilone as the active ingredient.

These products have undergone FDA’s rigorous approval process and have been determined to be safe and effective for their respective indications and dosing, and demonstrate the views of the IOM that the future of marijuana as a potential medicine lies in classical pharmacological drug development.7 As a result, patients who need medication can have confidence that any approved drug will be safe and effective for its indicated uses.

FDA’s Role in Supporting Development of New Therapies

FDA also plays a role in supporting the development of new drugs. This role broadly affects all of drug development. Because of FDA’s role as both a regulator and as a public health agency, FDA has a unique perspective on drug development, a perspective we use to identify and facilitate the development of new, innovative products to meet the needs of patients and the American public. We recognize that many scientific discoveries still need to be translated into treatments, even as patients are urgently waiting for new lifesaving therapies, and FDA is committed to helping bridge this gap.

As a part of this activity to streamline drug development, FDA has been actively scrutinizing, strengthening, and streamlining our regulatory processes at various steps along the path from drug discovery to delivery—including the clinical development phase, the longest and most expensive period of drug development. We have developed and successfully used a number of flexible and innovative approaches to expedite the development and review of drugs—to the benefit of millions of American patients. For instance, in 2014 almost two-thirds (26 of 41, 63 percent) of new molecular entities approved by CDER were approved in the United States before any other country.8 This is comparable to the previous year, 2013, in which almost three- quarters of CDER-approved new molecular entities (74 percent of 27) were approved first in the United States.9

FDA has several programs that directly facilitate and expedite development and review of new drugs that address unmet medical needs in the treatment of serious or life-threatening conditions: Fast Track10, Accelerated Approval11, Priority Review12, and Breakthrough Designation13. A look at recent drug approvals in CDER suggests that these programs have played an important role in bringing innovative drugs to market. Nearly half of the 27 novel drugs approved by CDER in 2013 took advantage of at least one of these expedited drug development and review approaches. Utilization of these accelerated programs was even more pronounced in 2014, with two-thirds (27 of 41) of novel drugs approved by CDER using at least one of these programs.

Development programs for drugs derived from marijuana and its constituents, including cannabidiol, may be eligible for these expedited review and development programs under appropriate circumstances and, in fact, some of these programs are currently being used in the development of such drugs. For example, in April 2014, GW Pharmaceuticals announced14 that FDA granted Fast-track designation to its investigational drug product Sativex®, composed primarily of two cannabinoids: cannabidiol and THC, administered as a metered-dose oromucosal spray, for the treatment of pain in patients with advanced cancer, who experience inadequate analgesia during optimized chronic opioid therapy. GW Pharmaceuticals has announced15 that Sativex is currently in Phase 3 clinical trials for this indication. In addition, on June 6, 2014, GW Pharmaceuticals announced16 that FDA granted Fast-track designation to its investigational cannabidiol product, Epidiolex®, in the treatment of Dravet syndrome, a rare and catastrophic treatment-resistant form of childhood epilepsy. In February 2015, Insys Therapeutics announced17 that FDA granted Fast-track designation to the cannabidiol formulation they are studying for the same condition.

As it does in other new drug development processes, FDA is working with researchers who are conducting studies on the development of new drugs derived from marijuana, including from its constituents such as cannabidiol, meeting with them regularly as they plan and carry out the trials as a part of their INDs. Although marijuana is a Schedule I substance, it can be, and is being, used in clinical trials conducted under INDs. A number of government-funded research projects involving marijuana or its component compounds, including cannabidiol, have been completed or are currently in progress, many of which are listed on the www.ClinicalTrials.gov website.

FDA also understands the interest in making investigational products available to patients while being studied for approval, and there are expanded access provisions in both FDA’s statute and its regulations to make this possible, where appropriate and where the manufacturer chooses to participate. FDA’s expanded access mechanisms are designed to facilitate the availability of investigational products to patients with serious diseases or conditions when there is no comparable or satisfactory alternative therapy available, either because the patients have exhausted treatment with, or are intolerant of, approved therapies, or because the patients are not eligible for an ongoing clinical trial.18 FDA cannot mandate or require a drug company to provide an unapproved drug to patients, and the availability of an investigational product through expanded access depends on the agreement of the drug company to make the drug available for the expanded access use, either through the company’s own expanded access program, or to a treating physician for administration to a patient or patients.

As noted, Epidiolex, containing cannabidiol, is being developed for the treatment of certain seizure disorders in children.19 GW Pharmaceuticals reports that 20 Epidiolex intermediate-size expanded access INDs have been authorized to treat approximately 420 children and that approximately 95 percent of Epidiolex expanded access INDs are for patients between 1 and 17 years of age.20

FDA also has worked with investigators to provide clear information on how to conduct research in this area. To help address common basic questions about research with marijuana, FDA, the National Institute on Drug Abuse (NIDA), and DEA have posted materials online to help researchers.21 We also know that a number of states are interested in allowing access to cannabidiol-containing oils to treat childhood epilepsy. FDA encourages and supports medical research into the safety and effectiveness of products containing cannabidiol and other marijuana constituents through adequate and well-controlled clinical trials conducted under an IND and consistent with DEA requirements for research on Schedule I substances. FDA has talked with representatives from several states considering support for medical research of marijuana and its derivatives, including cannabidiol, to provide scientific advice and to help ensure that their research is rigorous and appropriate.

FDA’s Role in Investigations and Enforcement Actions With Regard to Products Containing Cannabidiol

FDA recognizes that DEA is the lead Federal Government agency for enforcement matters related to the diversion of controlled substances, including marijuana. Historically, FDA has deferred to DEA regarding the illegal sale and use of illicit drugs of abuse, such as Schedule 1 drugs, which have no currently accepted medical use.

However, in addition to regulating medical products, FDA maintains regulatory oversight over foods, including dietary supplements. For any product found to be in violation of the FD&C Act, FDA considers many factors in deciding whether or not to initiate an enforcement action. Those factors include, among others, Agency resources and the threat to the public health. FDA also may consult with its Federal and state partners in making decisions about whether to initiate a Federal enforcement action.

In late February 2015, FDA issued several Warning Letters to firms that were marketing unapproved drugs for the diagnosis, cure, mitigation, treatment, or prevention of diseases. Some of these firms claimed that their products, which the firms made available nationwide via the Internet, contained cannabidiol which the firms claimed could help to address cancer, diabetes, multiple sclerosis, and other ailments. FDA tested those products and, in some, did not detect any cannabidiol.22 It is important to note that these products are not approved by FDA for the diagnosis, cure, mitigation, treatment, or prevention of any disease. Often they do not even contain the ingredients found on the label. Although FDA advised these firms that their products were in violation of the FD&C Act, and FDA is committed to keeping violative products off the market, consumers should be extremely cautious in purchasing and using such products. Marketing of products that are not what they claim to be, such as those purporting to contain cannabidiol but don’t, does more than simply defraud consumers who anticipate that the products purchased will contain the ingredients expected. These products and marketing can create false hope in a population especially vulnerable: those seeking relief from serious medical conditions for themselves or their loved ones, including their children. Moreover, it might divert patients from products with demonstrated safety and effectiveness.

The recent examples of the products being marketed to individuals seeking relief from serious medical conditions—products that FDA has not evaluated for safety and efficacy and that often do not even contain the ingredients they claim to contain—serves as another reminder of the important role FDA and the drug approval process play in this area.

CONCLUSION

FDA appreciates this opportunity to discuss the Agency’s work in the regulation of cannabidiol for potential medical uses in the United States, which is a part of FDA’s core mission to protect and promote the public health by helping to ensure the safety, efficacy, and quality of medical products, including drugs. There is considerable public interest in developing new therapies from marijuana and its constituents, especially cannabidiol. FDA will continue to play its role in ensuring that any such new therapies are safe, effective, and manufactured to a high quality, applying the drug development paradigm that continues to provide new medicines that meet these standards for patients. This paradigm, grounded in rigorous scientific research, is essential to determining any appropriate uses of marijuana and its constituents in the treatment of human disease. As a part of this important work, we are committed to collaborating with Federal and state agencies, researchers, and manufacturers also working on issues related to the use of cannabidiol and other constituents of marijuana in the United States. The drug approval process remains the best way to identify new treatments that are safe and effective for patients and to protect patients from products that are not what they purport to be.

Thank you for your interest in this important topic, and I am happy to answer any questions.


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#3 CatsAndBats

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Posted 15 December 2016 - 10:44 AM

Uh, have no idea what happened there.

 

Was just trying to post text from here:  http://www.fda.gov/N...y/ucm453989.htm


Edited by catattack, 15 December 2016 - 10:46 AM.

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#4 riseabovethought

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Posted 15 December 2016 - 12:08 PM

We wouldnt want all those people taking less pain killers now, would we?  It was actually the same kind of superior tech- suppression -thing with electric cars (invented in 1885). It makes you wonder if its really safety they are after, especially with safety firmly on the side of CBD oil.  This back room deal stinks of corruption.  Schedule One specifically means -No medical value.  Thats an impossible case to make.  Those guys are bought and sold $ell -outs.  Karma's gonna get em when their own kids are strung -out on pain killers, then heroine & crystal meth because of their twisted incoherent interference.


Edited by riseabovethought, 15 December 2016 - 12:41 PM.

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#5 Heirloom

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Posted 15 December 2016 - 04:10 PM

Thanks for posting this , I shouldn't be surprised at anything they do. This is doing way more harm as CBD is not a danger.
This is disturbing and very sad.


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#6 ethnobotanist420

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Posted 15 December 2016 - 07:50 PM

Oh yea we better nail that CBD!!! Horrible and dangerous drug that it is!

What about you dickheads tackle the fentanyl/carfentanyl epidemic?

No?
Too busy with CBD and Kratom?

You're right that makes waaaaayyyyyy more sense...

There are no words.
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#7 CatsAndBats

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Posted 15 December 2016 - 08:01 PM

Yes, it's ridiculous beyond measure.


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#8 ethnobotanist420

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Posted 15 December 2016 - 08:07 PM

It's pretty fucked up when this doesn't surprise me even in the tiniest bit...

I read the title and I literally thought "oh yea, that makes sense"

I mean it makes zero sense in reality but in the game they are playing I assume it makes total sense....
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#9 TVCasualty

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Posted 17 December 2016 - 01:28 PM

Here's to hoping that those corrupt assholes finally overplayed their hand and will get put in their place (which is the unemployment line).

 

If it hasn't already, a critical mass of the general public has (or soon will) become aware of the awesome medicinal potential of cannabis (heck, even Alabama has a law that went into effect earlier this year allowing the use of CBD oil in certain cases; baby steps...).

 

When you take away an effective medicine from those who need it, you tend to really piss them off. And since the fastest-growing demographic of cannabis consumers (in any context) is people over the age of 65 (a group that also tends to be rather protective of its interests at the polls; try messing with Social Security and see what happens...), this might just be enough to turn the tide of public support firmly against that peculiar and problematic (I'm being generous) Agency.


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#10 kcmoxtractor

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Posted 12 January 2017 - 11:15 AM

CBD extracts (since they're resin extracts of the hemp plant) have always

been on the FDA's list of prohibited substances, this is nothing new. i've been 

telling people for years that all those CBD products they were buying at the

headshop weren't legal for trade. 


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#11 ethnobotanist420

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Posted 12 January 2017 - 06:59 PM

CBD extracts (since they're resin extracts of the hemp plant) have always
been on the FDA's list of prohibited substances, this is nothing new. i've been
telling people for years that all those CBD products they were buying at the
headshop weren't legal for trade.


Very true.

We got a brief period of time where the law hadn't caught up to us and a wonderful medicine was being sold EVERYWHERE with next to no restrictions...

I think this has turned A LOT of people on to medical marijuana and probably even changed the minds of some anti-cannabis people... at the very least made them think about medical marijuana a little more deeply.

During this CBD "craze" where you could pick it up "legally" almost anywhere I think a lot of people were introduced to a new, safe option to treat various conditions and this is an amazing thing.

The fact the DEA then took it away was inevitable but there is a new fire in people's bellies about fixing the broken cannabis laws and I think we can thank the popularity of CBD for a lot of that.

Thanks for putting Cannabis on people's minds more than ever government dicks... thanks for the free advertising ;) lol
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#12 happy4nic8r

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Posted 12 January 2017 - 07:47 PM

the further they step into it, the more completely they will be easily buried.

 

just hope i live long enough to see it.


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#13 Arathu

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Posted 12 January 2017 - 08:26 PM

If there were such a major concern for protecting the public safety against all evils that cause the loss of life, property, and the environment, as I am supposed believe...............then I must ask where is the OUTRAGE for the automobile? How about making war and profiting from it? You want to get rid of a killer, you want to protect folks, you want to impose your self created righteousness, fucking ban cars and the possession of hydrocarbon fuels along with warfare....................yeah right! I hope their prescriptions and stock options bind their sphincters to the point of requiring surgical removal of what they are really full of............................


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#14 Ramble

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Posted 13 January 2017 - 12:04 AM

Fucking thugs man... this shit is beyond ridiculous
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#15 Lakegal7

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Posted 14 January 2017 - 02:13 PM

I think the drug companies are involved with this
There is so much benefit for so many with what cbd
Chrons, seizures, cancer..
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#16 Heirloom

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Posted 14 January 2017 - 02:58 PM

Clicked on this didn't expect to see you  but am not surprised.

I think the DEA is a paramilitary unit with law making capabilities that are unconstitional.

They operate as the military in country and out of country.

The CIA brings in hard drugs and the DEA busts the people for medicine ignoring the real problem.

To outlaw CBD is inhumane , no one uses CBD for recreation only medicine. CBD is anti psychoactive.

 We will continue on and break the unjust laws.

I can't remember  what revolutionary said it but "we will hang together or we will certainly hang alone"


I am more determined to grow high CBD plants to supply the needed medicine and provide the plants  to do so.



 


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